Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro

doi:10.1002/cbdv.201600487

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	Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro
	Yuan, Zhenzhen 1,2; Luan, Guangxiang 1,2; Wang, Zhenhua 3; Hao, Xueyan 3; Li, Ji 3; Suo, Yourui 1; Li, Gang 3; Wang, Honglun 1,4
	2017-06-01
发表期刊	CHEMISTRY & BIODIVERSITY
卷号	14 期号:6
文章类型	Article
摘要	Potentilla parvifolia FISCH. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects.
关键词	Potentilla Parvifolia Fisch. Flavonoids Neuroprotective Effects Sh-sy5y Cells Tau Phosphorylation
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1002/cbdv.201600487
关键词[WOS]	RETINOIC ACID ; INDUCED NEUROTOXICITY ; ALZHEIMERS-DISEASE ; AGRIMONIA-PILOSA ; DIFFERENTIATION ; ACTIVATION ; APOPTOSIS ; TAU ; ANTIOXIDANT ; EXPRESSION
收录类别	SCI
语种	英语
项目资助者	National Science Foundation of China(31470426 ; Qinghai Provincial Science Foundation(2015-SF-121 ; Taishan Scholar Program of Shandong Province(tshw201502046) ; Youth Innovation Promotion Association, CAS ; 21372190) ; 2014-ZJ-765)
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000405126900021
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/7075
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 4.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Zhenzhen,Luan, Guangxiang,Wang, Zhenhua,et al. Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro[J]. CHEMISTRY & BIODIVERSITY,2017,14(6).
APA	Yuan, Zhenzhen.,Luan, Guangxiang.,Wang, Zhenhua.,Hao, Xueyan.,Li, Ji.,...&Wang, Honglun.(2017).Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro.CHEMISTRY & BIODIVERSITY,14(6).
MLA	Yuan, Zhenzhen,et al."Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro".CHEMISTRY & BIODIVERSITY 14.6(2017).