Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity

doi:10.1093/chromsci/bmx020

NWIPB OpenIR

	Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity
	Chen, Tao 1,2; Li, Hongmei 1,2,3; Chen, Chen 1,2; Wei, Lixin 1,2; Li, Yulin 1,2
	2017-07-01
发表期刊	JOURNAL OF CHROMATOGRAPHIC SCIENCE
卷号	55 期号:6 页码:638-644
文章类型	Article
摘要	Large-scale preparation and alpha-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro alpha-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose. The study showed that swertioside had potential use as an anti-diabetic agent.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1093/chromsci/bmx020
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; COUNTER-CURRENT CHROMATOGRAPHY ; IONIC LIQUIDS ; PURIFICATION ; SEPARATION ; HPLC ; EXTRACT ; ROOT ; POLYSACCHARIDES ; COMBINATION
收录类别	SCI
语种	英语
项目资助者	"Personalized Medicines-Molecular Signaturebased Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12050304) ; Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources and General Program of Natural Science Foundation of Qinghai Province(2015-ZJ-908)
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS记录号	WOS:000404619700007
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/7079
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xinning Rd, Xining 810008, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, 23 Xinning Rd, Xining 810008, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Tao,Li, Hongmei,Chen, Chen,et al. Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE,2017,55(6):638-644.
APA	Chen, Tao,Li, Hongmei,Chen, Chen,Wei, Lixin,&Li, Yulin.(2017).Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity.JOURNAL OF CHROMATOGRAPHIC SCIENCE,55(6),638-644.
MLA	Chen, Tao,et al."Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity".JOURNAL OF CHROMATOGRAPHIC SCIENCE 55.6(2017):638-644.