Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products

doi:10.1039/c7fo00569e

NWIPB OpenIR

	Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products
	Zhang, Ming 1; Ma, Jianbin 2; Bi, Hongtao 1; Song, Jiayin 3; Yang, Hongxia 1,4; Xia, Zhenghua 1; Du, Yuzhi1,4 ; Gao, Tingting 4; Wei, Lixin1
	2017-08-01
发表期刊	FOOD & FUNCTION
ISSN	2042-6496
卷号	8 期号:8 页码:2771-2782
文章类型	Article
摘要	The Nitraria tangutorum Bobr. fruit is an indigenous berry of the shrub belonging to the Zygophyllaceae family which grows at an altitude of over 3000 m in the Tibetan Plateau, and has been used as a native medicinal food for treating weakness of the spleen, stomach syndrome, dyspepsia, neurasthenia, dizziness, etc. for thousands of years. Nowadays, N. tangutorum industrial juice by-products generated from health food production can be a potential low cost source of some unique bioactive ingredients. In a prior study, we established a simultaneous microwave/ultrasonic assisted enzymatic extraction method for extracting antioxidant ingredients from the industrial by-products of N. tangutorum juice. In this study, these ingredients were selectively fractionated by cation-exchange resin chromatography to obtain an anthocyanin fraction namely NJBAE. NJBAE was found to be composed of 16 anthocyanins derived from six anthocyanidins by HPLC-ESI-MS, and has an appreciable cardioprotective effect on doxorubicin-induced injured H9c2 cardiomyocytes. The cardioprotective mechanism research showed that NJBAE could directly scavenge ROS, restrict further generation of ROS, promote the activity of key antioxidase, enhance glutathione redox cycling, then affect the apoptotic signaling changes in a positive way, and finally mediate caspase-dependent cell death pathways. Therefore, NJBAE has great potential to be used for preventing and treating cardiovascular disease in the food, pharmaceutical and other emerging industries.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1039/c7fo00569e
关键词[WOS]	TANDEM MASS-SPECTROMETRY ; IN-VITRO ; LIQUID-CHROMATOGRAPHY ; ANTIOXIDANT ACTIVITY ; MEDICINAL-PLANTS ; OXIDATIVE STRESS ; TIBETAN PLATEAU ; HPLC-MS ; DOXORUBICIN ; GRAPE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(31400310 ; CAS "Light of West China" Program ; Applying Basic Research Program of Qinghai province(2015-ZJ-727) ; Key Laboratory Special Development Program of Qinghai Province(2017-ZJ-Y08) ; Natural Science Foundation of Tianjin City(15JCQNJC07500) ; 51408405)
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000407768600014
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/9798
专题	中国科学院西北高原生物研究所
通讯作者	Bi, Hongtao; Gao, Tingting; Wei, Lixin
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China 2.Qinghai Normal Univ, Sch Life & Geog Sci, Xining, Qinghai, Peoples R China 3.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ming,Ma, Jianbin,Bi, Hongtao,et al. Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products[J]. FOOD & FUNCTION,2017,8(8):2771-2782.
APA	Zhang, Ming.,Ma, Jianbin.,Bi, Hongtao.,Song, Jiayin.,Yang, Hongxia.,...&Wei, Lixin.(2017).Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products.FOOD & FUNCTION,8(8),2771-2782.
MLA	Zhang, Ming,et al."Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products".FOOD & FUNCTION 8.8(2017):2771-2782.