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Chloroplast phylogenomics and the taxonomy of Saxifraga section Ciliatae (Saxifragaceae) 期刊论文
ECOLOGY AND EVOLUTION, 2023, 卷号: 13, 期号: 1
作者:  Yuan, Rui;  Ma, Xiaolei;  Zhang, Zhuoxin;  Gornall, Richard J.;  Wang, Yongcui;  Chen, Shilong;  Gao, Qingbo
收藏  |  浏览/下载:46/0  |  提交时间:2023/12/01
基于核方法的协同药物组合预测方法 期刊论文
中国科学:生命科学, 2023, 卷号: 53, 期号: 11, 页码: 1663-1672
作者:  张竣;  袁锐;  陈世龙;  王永翠
收藏  |  浏览/下载:66/0  |  提交时间:2023/12/01
核方法  机器学习  相似性计算  协同药物组合  细胞系特异  
TCGA数据库4种消化系统癌症分子特征的比较 期刊论文
中国免疫学杂志, 2022, 卷号: 38, 期号: 18, 页码: 2252-2258
作者:  刘菲;  袁锐;  陈世龙;  王永翠
收藏  |  浏览/下载:43/0  |  提交时间:2022/12/04
消化系统癌症  TCGA数据库  癌症驱动基因  差异表达基因  差异甲基化基因  
Computational Probing the Methylation Sites Related to EGFR Inhibitor-Responsive Genes 期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 7
作者:  Yuan, Rui;  Chen, Shilong;  Wang, Yongcui
收藏  |  浏览/下载:66/0  |  提交时间:2021/11/18
DNA methylation  group lasso  CTRP and CCLE  lung cancer  EGFR inhibitors effectiveness related methylation sites  
DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2021, 卷号: 22, 期号: 5
作者:  Wang, Yongcui;  Yang, Yingxi;  Chen, Shilong;  Wang, Jiguang
收藏  |  浏览/下载:76/0  |  提交时间:2021/11/18
drug repurposing  multi-omics data sources  kernel-based data integration  machine learning  cancer precision medicine  
Computational Prediction of Drug Responses in Cancer Cell Lines From Cancer Omics and Detection of Drug Effectiveness Related Methylation Sites 期刊论文
FRONTIERS IN GENETICS, 2020, 卷号: 11
作者:  Yuan, Rui;  Chen, Shilong;  Wang, Yongcui
收藏  |  浏览/下载:65/0  |  提交时间:2020/11/25
cancer omics  DNA methylation  drug response  GDSC database  drug effectiveness related methylation sites  
Associating lncRNAs with small molecules via bilevel optimization reveals cancer-related lncRNAs 期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2019, 卷号: 15, 期号: 12
作者:  Wang, Yongcui;  Chen, Shilong;  Chen, Luonan;  Wang, Yong
收藏  |  浏览/下载:33/0  |  提交时间:2020/11/25
Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:  Wang, Yongcui;  Fang, Jianwen;  Chen, Shilong
收藏  |  浏览/下载:145/0  |  提交时间:2016/12/19
Computational Study of Drugs by Integrating Omics Data with Kernel Methods 期刊论文
MOLECULAR INFORMATICS, 2013, 卷号: 32, 期号: 11-12, 页码: 930-941
作者:  Wang, Yongcui C.;  Deng, Naiyang;  Chen, Shilong;  Wang, Yong;  Wang, YCC (reprint author), Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, 23 Xinning Rd, Xining, Qinghai Provinc, Peoples R China.
Adobe PDF(1222Kb)  |  收藏  |  浏览/下载:610/152  |  提交时间:2014/05/09
Omics Data  Kernel Methods  Data Integration  Drug-targets  Atc-codes Of Drugs  Drug Repositioning  
Drug Repositioning by Kernel-Based Integration of Molecular Structure, Molecular Activity, and Phenotype Data 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 11
作者:  Wang, Yongcui;  Chen, Shilong;  Deng, Naiyang;  Wang, Yong;  Wang, Y (reprint author), Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China.
Adobe PDF(1969Kb)  |  收藏  |  浏览/下载:425/81  |  提交时间:2014/05/09