Molecular Basis of Overdominance at a Flower Color Locus

doi:10.1534/g3.117.300336

NWIPB OpenIR

	Molecular Basis of Overdominance at a Flower Color Locus
	LaFountain, Amy M.1,2; Chen, Wenjie 1,3,4; Sun, Wei 5; Chen, Shilin 5; Frank, Harry A.2; Ding, Baoqing 1; Yuan, Yao-Wu 1
	2017-12-01
发表期刊	G3-GENES GENOMES GENETICS
ISSN	2160-1836
卷号	7 期号:12 页码:3947-3954
文章类型	Article
摘要	Single-gene overdominance is one of the major mechanisms proposed to explain heterosis (i.e., hybrid vigor), the phenomenon that hybrid offspring between two inbred lines or varieties show superior phenotypes to both parents. Although sporadic examples of single-gene overdominance have been reported over the decades, the molecular nature of this phenomenon remains poorly understood and it is unclear whether any generalizable principle underlies the various cases. Through bulk segregant analysis, chemical profiling, and transgenic experiments, we show that loss-of-function alleles of the FLAVONE SYNTHASE (FNS) gene cause overdominance in anthocyanin-based flower color intensity in the monkey-flower species Mimulus lewisii. FNS negatively affects flower color intensity by competing with the anthocyanin biosynthetic enzymes for the same substrates, yet positively affects flower color intensity by producing flavones, the colorless copigments required for anthocyanin stabilization, leading to enhanced pigmentation in the heterozyote (FNS/fns) relative to both homozygotes (FNS/FNS and fns/fns). We suggest that this type of antagonistic pleiotropy (i.e., alleles with opposing effects on different components of the phenotypic output) might be a general principle underlying single-gene overdominance.
关键词	Heterosis Mimulus Flavone Synthase Antagonistic Pleiotropy Anthocyanins
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1534/g3.117.300336
关键词[WOS]	MIMULUS-LEWISII ; INDUCED MUTATIONS ; HETEROSIS ; ANTHOCYANIN ; HYBRID ; GENE ; PIGMENTATION ; TOMATO ; MAIZE
收录类别	SCI
语种	英语
项目资助者	University of Connecticut ; National Science Foundation(IOS-1558083) ; University of Connecticut Research Foundation
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000417073900011
出版者	GENETICS SOCIETY AMERICA
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13276
专题	中国科学院西北高原生物研究所
通讯作者	Yuan, Yao-Wu
作者单位	1.Univ Connecticut, Dept Ecol & Evolutionary Biol, 75 N Eagleville Rd,Unit 3043, Storrs, CT 06269 USA 2.Univ Connecticut, Dept Chem, Storrs, CT 06269 USA 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China 4.Key Lab Crop Mol Breeding Qinghai Prov, Xining 810008, Qinghai, Peoples R China 5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
推荐引用方式 GB/T 7714	LaFountain, Amy M.,Chen, Wenjie,Sun, Wei,et al. Molecular Basis of Overdominance at a Flower Color Locus[J]. G3-GENES GENOMES GENETICS,2017,7(12):3947-3954.
APA	LaFountain, Amy M..,Chen, Wenjie.,Sun, Wei.,Chen, Shilin.,Frank, Harry A..,...&Yuan, Yao-Wu.(2017).Molecular Basis of Overdominance at a Flower Color Locus.G3-GENES GENOMES GENETICS,7(12),3947-3954.
MLA	LaFountain, Amy M.,et al."Molecular Basis of Overdominance at a Flower Color Locus".G3-GENES GENOMES GENETICS 7.12(2017):3947-3954.