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Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro
Luan, Guangxiang1,3,4; Wang, Yuwei1,3,4; Wang, Zhenhua2; Zhou, Wenna1,3,4; Hu, Na1,3; Li, Gang2; Wang, Honglun1,3
2018-03-28
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号66期号:12页码:3169-3178
文章类型Article
摘要Fenugreek is a well known annual herb widely used in both medicine and food. Four flavonoid glycosides have been separated from fenugreek seeds in our previous study. In this study, the effects of the four flavonoid glycosides on regulating glycolipid metabolism and improving mitochondrial function were investigated. Isoorientin showed a very significant activity among these flavonoid glycosides. First, isoorientin decreased the accumulation of lipid droplets in 3T3-L1 preadipocytes by reducing the expression of adipokines including PPARy, C/EBP alpha, and FAS. Second, isoorientin restored insulin-stimulated glucose uptake in dexamethasone-induced insulin-resistant 3T3-L1 adipocytes by reactivating Akt and AMPK. Finally, isoorientin improved mitochondrial dysfunction induced by dexamethasone in 3T3-L1 adipocytes. Isoorientin also reversed dexamethasone-induced decrease in mitochondrial membrane potential (MMP) and intracellular ATP production, reduced accumulation of intracellular reactive oxygen species (ROS), and protected mitochondrial DNA (mtDNA) from oxidative damage. At the same time, mitochondrial biogenesis is promoted. Therefore, isoorientin may be an attractive candidate as a glucose-lowering and insulin-resistance-improving agent for the treatment of diabetes.
关键词Fenugreek Seeds Flavonoid Glycosides Isoorientin Insulin Resistance 3t3-l1 Adipocytes Mitochondrial Function
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.jafc.8b00179
关键词[WOS]TRIGONELLA-FOENUM-GRAECUM ; INDUCED DIABETIC-RATS ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; OXIDATIVE STRESS ; QUANTITATIVE PCR ; GLUCOSE-UPTAKE ; BLOOD-GLUCOSE ; PPAR-GAMMA ; OBESITY
收录类别SCI
语种英语
项目资助者National Science Foundation of China(31470426) ; Qinghai Provincial Science Foundation(2015-SF-121) ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development" ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040320) ; Shandong Provincial Science Foundation(ZR2017MH024) ; Shuangbai Project of Yantai ; Youth Innovation Promotion Association, CAS
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
WOS类目Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号WOS:000428972400016
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13351
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
2.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China
3.Key Lab Tibetan Med Res Qinghai Prov, 251 Ningda Rd, Xining, Qinghai, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Luan, Guangxiang,Wang, Yuwei,Wang, Zhenhua,et al. Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(12):3169-3178.
APA Luan, Guangxiang.,Wang, Yuwei.,Wang, Zhenhua.,Zhou, Wenna.,Hu, Na.,...&Wang, Honglun.(2018).Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(12),3169-3178.
MLA Luan, Guangxiang,et al."Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.12(2018):3169-3178.
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