Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells | |
Xia, Zhenjiang1,2,3; Wei, Lixin1,2; Du, Yuzhi1,2; Wang, Lulu4,5,6; Han, Jichun4,5,6; He, Qiangqiang1,2,3; Chen, Haijuan1,2,3; Zou, Xiaoyan1,2,3; Wu, Huali4,5,6; Shang, Jing1,2,4,5,6 | |
2018-08-01 | |
发表期刊 | CHEMICAL & PHARMACEUTICAL BULLETIN |
ISSN | 0009-2363 |
卷号 | 66期号:8页码:818-821 |
文章类型 | Article |
摘要 | Zuotai is a drug containing mercury considered to be the king of Tibetan medicine. The biosafety of Zuotai led people's attention and so far little is known about the toxicity of Zuotai to mast cells. RBL-2H3 cells which used as an alternative model of mast cells were treated with Zuotai, beta-HgS and positive drug Compound 48/80 respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the toxicity of drugs to RBL-2H3 cells. The degranulation of RBL-2H3 cells was studied from beta-hexosaminidase, histamine, interleukin (IL)-4 and tumor necrosis factor-alpha (TNF-alpha). The result showed that Zuotai can affect the cytotoxicity and degranulation of RBL-2H3 cells and the results can provide reference for the toxicity evaluations of Tibetan medicine Zuotai. |
关键词 | Tibetan Medicine Zuotai Mercury Cytotoxicity Rbl-2h3 Cell |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
关键词[WOS] | MAST-CELLS |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | One Hundred Person Project of the Chinese Academy of Sciences(Y229461211) ; Applied Basic Research Programs of Qinghai Province ; Science and Technology Plan Projects in Qinghai Province(2015-ZJ-733) |
WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
WOS类目 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000440878700007 |
出版者 | PHARMACEUTICAL SOC JAPAN |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/13783 |
专题 | 中国科学院西北高原生物研究所 |
通讯作者 | Shang, Jing |
作者单位 | 1.Chinese Acad Sci, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 2.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China 5.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China 6.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Zhenjiang,Wei, Lixin,Du, Yuzhi,et al. Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2018,66(8):818-821. |
APA | Xia, Zhenjiang.,Wei, Lixin.,Du, Yuzhi.,Wang, Lulu.,Han, Jichun.,...&Shang, Jing.(2018).Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells.CHEMICAL & PHARMACEUTICAL BULLETIN,66(8),818-821. |
MLA | Xia, Zhenjiang,et al."Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells".CHEMICAL & PHARMACEUTICAL BULLETIN 66.8(2018):818-821. |
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