The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats

doi:10.5194/aab-61-329-2018

NWIPB OpenIR

	The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats
	Yan, Hailong 1,2,3; Jiang, Enhui 3; Zhu, Haijing 1,2; Hu, Linyong4 ; Liu, Jinwang 1,2; Qu, Lei 1,2
	2018-08-09
发表期刊	ARCHIVES ANIMAL BREEDING
ISSN	0003-9438
卷号	61 期号:3 页码:329-336
文章类型	Article
摘要	The paired-like homeodomain 2 (PITX2) gene plays a critical role in regulating development, reproduction, and growth traits in ruminants. Hence, the objective of this study was to explore the polymorphisms of this gene and to evaluate their associations with quantitative traits. Herein, a novel insertion in the promoter region of the PITX2 gene was reported in Shaanbei white cashmere (SBWC) goats (n = 1012). The genotype distributions between mothers of single-kid and multi-kid groups within SBWC goats were significantly different (P < 0.01), implying that this indel mutation might affect the litter size. Furthermore, association analysis found that this indel mutation was significantly associated with litter size (P = 0.001). Individuals with genotype DD had a significantly smaller litter size than those with other genotypes (P < 0.01). Besides, this indel was significantly associated with the body length (P = 0.042) and the chest width (P = 0.031). Especially, the individuals with genotype DD had a significantly lower body length than those with genotype II (P < 0.05), which was consistent with the trend in litter size. These findings suggested that the new 22 bp indel mutation within the PITX2 gene is significantly associated with litter size and growth traits; this can be utilized as a functional molecular marker in goat breeding.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.5194/aab-61-329-2018
关键词[WOS]	AXENFELD-RIEGER SYNDROME ; ATRIAL-FIBRILLATION ; INDEL ; TRANSCRIPTION ; IDENTIFICATION ; EXPRESSION ; SHEEP
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(31760650 ; Provincial Key Projects of Shaanxi(2014KTDZ02-01) ; Applied Basic Research Program of Qinghai Province(2014-ZJ-710) ; West Light Foundation of The Chinese Academy of Sciences ; 31702115)
WOS研究方向	Agriculture
WOS类目	Agriculture, Dairy & Animal Science
WOS记录号	WOS:000441170300001
出版者	COPERNICUS GESELLSCHAFT MBH
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13785
专题	中国科学院西北高原生物研究所
通讯作者	Qu, Lei
作者单位	1.Yulin Univ, Shaanxi Prov Engn & Technol Res Ctr Cashmere Goat, Yulin 719000, Peoples R China 2.Yulin Univ, Life Sci Res Ctr, Yulin 719000, Peoples R China 3.Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Yan, Hailong,Jiang, Enhui,Zhu, Haijing,et al. The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats[J]. ARCHIVES ANIMAL BREEDING,2018,61(3):329-336.
APA	Yan, Hailong,Jiang, Enhui,Zhu, Haijing,Hu, Linyong,Liu, Jinwang,&Qu, Lei.(2018).The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats.ARCHIVES ANIMAL BREEDING,61(3),329-336.
MLA	Yan, Hailong,et al."The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats".ARCHIVES ANIMAL BREEDING 61.3(2018):329-336.