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The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats
Yan, Hailong1,2,3; Jiang, Enhui3; Zhu, Haijing1,2; Hu, Linyong4; Liu, Jinwang1,2; Qu, Lei1,2
2018-08-09
Source PublicationARCHIVES ANIMAL BREEDING
ISSN0003-9438
Volume61Issue:3Pages:329-336
SubtypeArticle
AbstractThe paired-like homeodomain 2 (PITX2) gene plays a critical role in regulating development, reproduction, and growth traits in ruminants. Hence, the objective of this study was to explore the polymorphisms of this gene and to evaluate their associations with quantitative traits. Herein, a novel insertion in the promoter region of the PITX2 gene was reported in Shaanbei white cashmere (SBWC) goats (n = 1012). The genotype distributions between mothers of single-kid and multi-kid groups within SBWC goats were significantly different (P < 0.01), implying that this indel mutation might affect the litter size. Furthermore, association analysis found that this indel mutation was significantly associated with litter size (P = 0.001). Individuals with genotype DD had a significantly smaller litter size than those with other genotypes (P < 0.01). Besides, this indel was significantly associated with the body length (P = 0.042) and the chest width (P = 0.031). Especially, the individuals with genotype DD had a significantly lower body length than those with genotype II (P < 0.05), which was consistent with the trend in litter size. These findings suggested that the new 22 bp indel mutation within the PITX2 gene is significantly associated with litter size and growth traits; this can be utilized as a functional molecular marker in goat breeding.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.5194/aab-61-329-2018
WOS KeywordAXENFELD-RIEGER SYNDROME ; ATRIAL-FIBRILLATION ; INDEL ; TRANSCRIPTION ; IDENTIFICATION ; EXPRESSION ; SHEEP
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31760650 ; Provincial Key Projects of Shaanxi(2014KTDZ02-01) ; Applied Basic Research Program of Qinghai Province(2014-ZJ-710) ; West Light Foundation of The Chinese Academy of Sciences ; 31702115)
WOS Research AreaAgriculture
WOS SubjectAgriculture, Dairy & Animal Science
WOS IDWOS:000441170300001
PublisherCOPERNICUS GESELLSCHAFT MBH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13785
Collection中国科学院西北高原生物研究所
Corresponding AuthorQu, Lei
Affiliation1.Yulin Univ, Shaanxi Prov Engn & Technol Res Ctr Cashmere Goat, Yulin 719000, Peoples R China
2.Yulin Univ, Life Sci Res Ctr, Yulin 719000, Peoples R China
3.Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Yan, Hailong,Jiang, Enhui,Zhu, Haijing,et al. The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats[J]. ARCHIVES ANIMAL BREEDING,2018,61(3):329-336.
APA Yan, Hailong,Jiang, Enhui,Zhu, Haijing,Hu, Linyong,Liu, Jinwang,&Qu, Lei.(2018).The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats.ARCHIVES ANIMAL BREEDING,61(3),329-336.
MLA Yan, Hailong,et al."The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats".ARCHIVES ANIMAL BREEDING 61.3(2018):329-336.
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