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New fluorescent labeling reagent Benzimidazo[2,1-b]quinazoline-12 (6H) -one-5-ethylimidazole ester and its application in the analysis of endocrine disrupting compounds in milk by high performance liquid chromatography with fluorescence detection
Liu, Jiamin1; You, Jinmao1,2; Zhang, Shijuan1; Song, Cuihua1; Ji, Zhongyin2; Zhuang, Jianlin1; Yu, Yanxin1
2018-05-01
Source PublicationMICROCHEMICAL JOURNAL
ISSN0026-265X
Volume138Pages:309-315
SubtypeArticle
AbstractA new fluorescent labeling reagent, benzimidazo[2,1-b]quinazoline-12(6H)-one-5-ethylimidazole ester (BQEIC), was designed and synthesized, and successfully applied to the analysis of endocrine-disrupting compounds (EDCs) by high performance liquid chromatography (HPLC) with fluorescence detection. BQEIC reacted with EDCs under mild conditions with 4-dimethylaminopyridine as basic catalyst. The derivatives showed excellent fluorescence property with excitation and emission wavelength of 302 nm and 401 nm respectively. Under the optimal conditions, good linearity was observed in the concentration range of 20.0 to 200 mu g L-1 with correlation coefficients of >0.996. The limits of detection and limits of quantification were in the range of 10.5-13.8 and 33.1-37.9 ng L-1, respectively. The average recoveries (n = 3) were in the range of 92.6-98.5%. The developed method was successfully applied to analyze the EDCs residues in milk samples. (C) 2018 Elsevier B.V. All rights reserved.
KeywordEndocrine Disrupting Compounds Derivatization High Performance Liquid Chromatography Fluorescence Detection Benzimidazo[2 1-b]Quinazoline-12 (6h) -one-5-ethylimidazole Ester
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.microc.2018.01.029
WOS KeywordTANDEM MASS-SPECTROMETRY ; PRESSURE CHEMICAL-IONIZATION ; BISPHENOL-A ; ENVIRONMENTAL MATRICES ; GAS-CHROMATOGRAPHY ; WASTE-WATER ; ESTROGENS ; SAMPLES ; EXTRACTION ; MICROEXTRACTION
Indexed BySCI
Language英语
Funding OrganizationNational Science Foundation of China(21275089) ; Natural Science Foundation of Shandong Province(ZR2015CM040) ; National Undergraduate Training Program for Innovation and Entrepreneurship of China(201710446036)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000428103000035
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13845
Collection中国科学院西北高原生物研究所
Corresponding AuthorYou, Jinmao; Zhang, Shijuan
Affiliation1.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med S, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jiamin,You, Jinmao,Zhang, Shijuan,et al. New fluorescent labeling reagent Benzimidazo[2,1-b]quinazoline-12 (6H) -one-5-ethylimidazole ester and its application in the analysis of endocrine disrupting compounds in milk by high performance liquid chromatography with fluorescence detection[J]. MICROCHEMICAL JOURNAL,2018,138:309-315.
APA Liu, Jiamin.,You, Jinmao.,Zhang, Shijuan.,Song, Cuihua.,Ji, Zhongyin.,...&Yu, Yanxin.(2018).New fluorescent labeling reagent Benzimidazo[2,1-b]quinazoline-12 (6H) -one-5-ethylimidazole ester and its application in the analysis of endocrine disrupting compounds in milk by high performance liquid chromatography with fluorescence detection.MICROCHEMICAL JOURNAL,138,309-315.
MLA Liu, Jiamin,et al."New fluorescent labeling reagent Benzimidazo[2,1-b]quinazoline-12 (6H) -one-5-ethylimidazole ester and its application in the analysis of endocrine disrupting compounds in milk by high performance liquid chromatography with fluorescence detection".MICROCHEMICAL JOURNAL 138(2018):309-315.
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