Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification

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	Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification
	You, Jinmao 1,2; Song, Cuihua 2; Fu, Yanyan 2; Sun, Zhiwei 1,3; Xia, Lian 1; Xia, Yulin 1; Suo, Yourui 1
	2010-01-15
发表期刊	TALANTA
ISSN	0039-9140
卷号	80 期号:3 页码:1392-1399
文章类型	Article
摘要	Dual-sensitive probe of 1-imidazole-2-(5-benzoacridine)-ethanone (IBAE) for the determination of free amines with fluorescence detection and online highly sensitive atmospheric chemical ionization-mass spectrometry identification (APCI-MS) has been developed. 2-(Benzoacridine)-5-acetic acid (BAAA) reacts with coupling agent N,N'-carbonyldiimidazole (CDI) to form a highly activated amide intermediate 1-imidazole-2-(5-benzoacridine)-ethanone (IBAE), which is dual-sensitive probe. The amide intermediate (IBAE) reacts preferably with amines in dimethylformamide (DMF) solvent to give the high yields of derivatives. IBAE-amine derivatives are not only sensitive to fluorescence but also to MS ionizable efficiency. The percent ionization 6 values change from 0 to 57.32% in aqueous acetonitrile and from 0 to 62.14% in aqueous methanol. The relative standard deviations of the peak areas with fluorescence detection for each amine are <1.24% (40 ng/ml, n = 6). The fluorescence detection limits (at a signal-to-noise ratio of 3) are in the range of 0.15-0.50 ng/ml. The online APCI-MS detection limits are in the range of 2.07-8.51 ng/ml (at a signal-to-noise ratio of 3). Therefore, the facile IBAE intermediate derivatization allowed the development of a highly sensitive and specific method for the quantitative analysis of trace levels of amines in environmental water. (C) 2009 Elsevier B.V. All rights reserved.; Dual-sensitive probe of 1-imidazole-2-(5-benzoacridine)-ethanone (IBAE) for the determination of free amines with fluorescence detection and online highly sensitive atmospheric chemical ionization-mass spectrometry identification (APCI-MS) has been developed. 2-(Benzoacridine)-5-acetic acid (BAAA) reacts with coupling agent N,N'-carbonyldiimidazole (CDI) to form a highly activated amide intermediate 1-imidazole-2-(5-benzoacridine)-ethanone (IBAE), which is dual-sensitive probe. The amide intermediate (IBAE) reacts preferably with amines in dimethylformamide (DMF) solvent to give the high yields of derivatives. IBAE-amine derivatives are not only sensitive to fluorescence but also to MS ionizable efficiency. The percent ionization 6 values change from 0 to 57.32% in aqueous acetonitrile and from 0 to 62.14% in aqueous methanol. The relative standard deviations of the peak areas with fluorescence detection for each amine are <1.24% (40 ng/ml, n = 6). The fluorescence detection limits (at a signal-to-noise ratio of 3) are in the range of 0.15-0.50 ng/ml. The online APCI-MS detection limits are in the range of 2.07-8.51 ng/ml (at a signal-to-noise ratio of 3). Therefore, the facile IBAE intermediate derivatization allowed the development of a highly sensitive and specific method for the quantitative analysis of trace levels of amines in environmental water. (C) 2009 Elsevier B.V. All rights reserved.
关键词	Hplc Amines Fluorescence Mass Spectrometry 2-(Benzoacridine)-5-acetic Acid (Baaa) 1-imidazole-2-(5-benzoacridine)-ethanone (Ibae)
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	LIQUID-CHROMATOGRAPHIC DETERMINATION ; CAPILLARY-ZONE-ELECTROPHORESIS ; PRECOLUMN DERIVATIZATION ; ALIPHATIC-AMINES ; 2-(9-ANTHRYL)ETHYL CHLOROFORMATE ; N-NITROSOAMINES ; WASTE-WATER ; APCI-MS ; ACIDS ; CHLORIDE
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
WOS记录号	WOS:000273929900053
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/1756
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China 2.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	You, Jinmao,Song, Cuihua,Fu, Yanyan,et al. Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification[J]. TALANTA,2010,80(3):1392-1399.
APA	You, Jinmao.,Song, Cuihua.,Fu, Yanyan.,Sun, Zhiwei.,Xia, Lian.,...&Suo, Yourui.(2010).Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification.TALANTA,80(3),1392-1399.
MLA	You, Jinmao,et al."Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification".TALANTA 80.3(2010):1392-1399.