Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS

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	Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS
	Fu Yan-Yan 2; Sun Zhi-Wei 1,3; Zhao Huai-Xin 2; Bai Xin-Wei 2; Suo You-Rui 1; Li Yu-Lin 1; You Jin-Mao 1,2
	2009-11-10
发表期刊	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN	0251-0790
卷号	30 期号:11 页码:2146-2153
文章类型	Article
摘要	2-{12-Oxobenzo[b] acridin-5(12H)-yl} -acetic acid (BAAA) reacted with coupling agent N, N'-carbonyldiimidazole (CDI) to form an activated amide intermediate 5-[2-(1H-imidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one(IEBA), which was a novel fluorescence probe. The amide intermediate(IEBA) reacted preferably with amines in DMF solvent in the absence of catalysts to give the high yields of derivatives, which not only have high fluorescence sensitivity but also have strong ionizable ability. The optimum excitation and emission wavelengths were at lambda(ex)/lambda(em) = 272 nm/505 nm. The percent ionization 8 values in aqueous acetonitrile and aqueous methanol were in the range of 0-57. 32% and 0-62. 14%, respectively. The fluorescence detection limits of twelve amine derivatives(at a signal-to-noise ratio of 3) were in the range of 0. 15-0. 50 ng/mL. The online APCI-MS detection limits were at levels of 1. 43-8. 51 ng/mL(S/N = 3).; 2-{12-Oxobenzo[b] acridin-5(12H)-yl} -acetic acid (BAAA) reacted with coupling agent N, N'-carbonyldiimidazole (CDI) to form an activated amide intermediate 5-[2-(1H-imidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one(IEBA), which was a novel fluorescence probe. The amide intermediate(IEBA) reacted preferably with amines in DMF solvent in the absence of catalysts to give the high yields of derivatives, which not only have high fluorescence sensitivity but also have strong ionizable ability. The optimum excitation and emission wavelengths were at lambda(ex)/lambda(em) = 272 nm/505 nm. The percent ionization 8 values in aqueous acetonitrile and aqueous methanol were in the range of 0-57. 32% and 0-62. 14%, respectively. The fluorescence detection limits of twelve amine derivatives(at a signal-to-noise ratio of 3) were in the range of 0. 15-0. 50 ng/mL. The online APCI-MS detection limits were at levels of 1. 43-8. 51 ng/mL(S/N = 3).
关键词	High Performance Liquid Chromatography/ion-trap Mass Spectrometry Percent Ionization 2-{12-oxobenzo[b] Acridin-5 (12h)-yl]-acetic Acid 5-[2-(1h-imidazol-1-yl)-2-oxoethyl] Benzo [b] Acridin-12 (5h)-one
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; VOLATILE N-NITROSAMINES ; DERIVATIZATION ; WATER ; HPLC ; IDENTIFICATION ; PRODUCTS ; REAGENT
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000272832200010
引用统计
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/1806
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China 2.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Fu Yan-Yan,Sun Zhi-Wei,Zhao Huai-Xin,et al. Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(11):2146-2153.
APA	Fu Yan-Yan.,Sun Zhi-Wei.,Zhao Huai-Xin.,Bai Xin-Wei.,Suo You-Rui.,...&You Jin-Mao.(2009).Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(11),2146-2153.
MLA	Fu Yan-Yan,et al."Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.11(2009):2146-2153.