NWIPB OpenIR
ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample
Huang, Lunjie ; Chen, Kai ; Zhang, Wentao ; Zhu, Wenxin ; Liu, Xinnan ; Wang, Jing ; Wang, Rong ; Hu, Na ; Suo, Yourui ; Wang, Jianlong
2018-09-15
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
AbstractNanozyme technique with efficient modulating strategies is a promising tool for biocatalytic and biosensing applications, yet insights into target-responsive controllability of oxidase nanozymes remain largely unknown. In this contribution, we report a state-of-art oxidase-like and ssDNA-tunable nanozyme for biomolecular recognition. In detail, the spinel-type manganese cation substituted cobalt oxide (MnCo2O4) submicrospheres can imitate oxidase for efficiently catalytic oxidation of colorimetric substrate, superior to current metal oxide-based oxidase nanozymes. More importantly, the nanozyme activity of spinel MnCo2O4 can be reversibly inhibited by the attachment/detachment of aptamer strands on MnCo2O4 surface via the aptamer-target binding event, enabling a new colorimetric access for detecting biomolecules. Taking highly toxic ochratoxin A (OTA) as model molecule, we can selectively determine OTA in maize samples with a limit of detection (3 delta/S) of 0.08 ng/mL. The unique nanozyme property of spinel MnCo2O4, together with the principle of our approach, reveals the potential of ssDNA-tailorable oxidase nanozymes in biocatalytic and biosensing fields. (C) 2018 Elsevier B.V. All rights reserved.
PublisherELSEVIER SCIENCE SA
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/18918
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Huang, Lunjie,Chen, Kai,Zhang, Wentao,et al. ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018.
APA Huang, Lunjie.,Chen, Kai.,Zhang, Wentao.,Zhu, Wenxin.,Liu, Xinnan.,...&Wang, Jianlong.(2018).ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample.SENSORS AND ACTUATORS B-CHEMICAL.
MLA Huang, Lunjie,et al."ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample".SENSORS AND ACTUATORS B-CHEMICAL (2018).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Lunjie]'s Articles
[Chen, Kai]'s Articles
[Zhang, Wentao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Lunjie]'s Articles
[Chen, Kai]'s Articles
[Zhang, Wentao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Lunjie]'s Articles
[Chen, Kai]'s Articles
[Zhang, Wentao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.