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Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch
Wei LX(魏立新); Peng M(彭敏)
2010-04-18
Source PublicationJournal of Medicinal Plants Research
ISSN1996-0875
Volume4Issue:8Pages:706-709
AbstractSwertia mussotii Franch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics of Swertia mussotii Franch., the whole plant of Swertia mussotii was extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedimentation was SME-d. 17.76% SME-a, 14.48% SME-b, 10.13% SME-c, and 4.35%SME-d were extracted from Swertia mussotii. These four extracts were evaluated with acute toxicity and hepatoprotective effect on CCl4-induced acute liver damage in mice. The toxic material mainly reside in SME-c and SME-a. The hepatoprotective materials were in SME-a, SME-c and SME-d, while SME-b had no hepatoprotective activities. So, SME-a and SME-c had both the hepatoprotection and toxicity characteristics; SME-b had no toxicity or the hepatoprotection characteristics; only SME-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder.
Indexed BySCI
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/2068
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Wei LX,Peng M. Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch[J]. Journal of Medicinal Plants Research,2010,4(8):706-709.
APA 魏立新,&彭敏.(2010).Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.Journal of Medicinal Plants Research,4(8),706-709.
MLA 魏立新,et al."Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch".Journal of Medicinal Plants Research 4.8(2010):706-709.
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