Chemical constituents of Euphorbia tangutica

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	Chemical constituents of Euphorbia tangutica
	Zhang, Ben-Yin 1,5; Wang, Huan 1; Luo, Xiao-Dong 2; Du, Zhi-Zhi 2; Wu, Hai-Feng 3,4; Shen, Jian-Wei 1; Zhang, Xiao-feng 1
	2012
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	26 期号:24 页码:2309-2315
文章类型	Article
摘要	Sixteen known compounds isolated from the whole plants of Euphorbia tangutica, including phorbol-13-actate (1) previously synthesised and obtained from a natural source for the first time, were evaluated in vitro against a panel of human cancer cell lines using the MTT method. Among them, ergosterol (6) exhibited significant cytotoxic activity against HL-60 cell line with an IC50 value of 3.3 mu M, and 3 beta,5 alpha-dihydroxy-15 beta-cinnamoyloxy-14-oxolathyra-6Z,12 E-diene (7) also displayed moderate activity.; Sixteen known compounds isolated from the whole plants of Euphorbia tangutica, including phorbol-13-actate (1) previously synthesised and obtained from a natural source for the first time, were evaluated in vitro against a panel of human cancer cell lines using the MTT method. Among them, ergosterol (6) exhibited significant cytotoxic activity against HL-60 cell line with an IC50 value of 3.3 mu M, and 3 beta,5 alpha-dihydroxy-15 beta-cinnamoyloxy-14-oxolathyra-6Z,12 E-diene (7) also displayed moderate activity.
关键词	Euphorbiaceae Euphorbia Tangutica Phorbol-13-actate Ergosterol Cytotoxic Activity
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]	MACROCYCLIC DITERPENES ; TOXICITY ; ESTERS
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000310608200004
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/3738
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810008, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China 4.Peking Union Med Coll, Beijing 100193, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ben-Yin,Wang, Huan,Luo, Xiao-Dong,et al. Chemical constituents of Euphorbia tangutica[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2309-2315.
APA	Zhang, Ben-Yin.,Wang, Huan.,Luo, Xiao-Dong.,Du, Zhi-Zhi.,Wu, Hai-Feng.,...&Zhang, Xiao-feng.(2012).Chemical constituents of Euphorbia tangutica.NATURAL PRODUCT RESEARCH,26(24),2309-2315.
MLA	Zhang, Ben-Yin,et al."Chemical constituents of Euphorbia tangutica".NATURAL PRODUCT RESEARCH 26.24(2012):2309-2315.

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