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Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways
Jiang, Lei ; Zhao, Xiaoying ; Pei, Jinjin ; Mei, Lijuan ; Cui, Yulei ; Wang, Shuo ; Shao, Yun ; Zhang, Xiaoling ; Tao, Yanduo
2017-10-01
发表期刊JOURNAL OF FUNCTIONAL FOODS
摘要Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases. (C) 2017 Elsevier Ltd. All rights reserved.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/38498
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Jiang, Lei,Zhao, Xiaoying,Pei, Jinjin,et al. Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways[J]. JOURNAL OF FUNCTIONAL FOODS,2017.
APA Jiang, Lei.,Zhao, Xiaoying.,Pei, Jinjin.,Mei, Lijuan.,Cui, Yulei.,...&Tao, Yanduo.(2017).Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways.JOURNAL OF FUNCTIONAL FOODS.
MLA Jiang, Lei,et al."Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways".JOURNAL OF FUNCTIONAL FOODS (2017).
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