Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE | |
| Zhao, Xiao-Hui1,2,3; Yue, Hui-Lan1; Li, Ping4; Zeng, Xin4; Zhang, Gen5; Zeng, X (reprint author), Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, State Key Lab Reprod Med, Dept Gynecol Endocrine, Nanjing 210029, Jiangsu, Peoples R China. | |
| 2013-06-01 | |
| 发表期刊 | NANO
 |
| ISSN | 1793-2920 |
| 卷号 | 8期号:3 |
| 文章类型 | Article |
| 摘要 | Cadmium telluride quantum dots (QDs) have received significant attention in biomedical research because of their potential in drug delivery. In this study, the chemotherapeutic agent Verbascoside (VB) was immobilized successfully onto CdTe QDs by covalent bonding between the -OH group of VB and the -COOH group of CdTe QDs. The amount of VB that could be immobilized depended on the concentration of -COOH groups (succinic acid) on the surface of the CdTe QDs. Apoptotic staining, DNA fragmentation and flow cytometry analysis further demonstrated that compared with CdTe QDs or VB treatment alone, the apoptosis rate increased after the treatment of CdTe QDs together with VB (VB-QDs) in HepG2/ADM cells. We observed that VB-QDs treatment could clearly activate apoptosis-related Caspase 3 expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of VB-QDs effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus, VB-QDs may serve as a possible alternative for therapeutic approaches for some cancer treatments. In summary, studies have shown that cancer cells are treated by the presence of VB-QDs nanoparticles based on analysis of cell apoptosis.; Cadmium telluride quantum dots (QDs) have received significant attention in biomedical research because of their potential in drug delivery. In this study, the chemotherapeutic agent Verbascoside (VB) was immobilized successfully onto CdTe QDs by covalent bonding between the -OH group of VB and the -COOH group of CdTe QDs. The amount of VB that could be immobilized depended on the concentration of -COOH groups (succinic acid) on the surface of the CdTe QDs. Apoptotic staining, DNA fragmentation and flow cytometry analysis further demonstrated that compared with CdTe QDs or VB treatment alone, the apoptosis rate increased after the treatment of CdTe QDs together with VB (VB-QDs) in HepG2/ADM cells. We observed that VB-QDs treatment could clearly activate apoptosis-related Caspase 3 expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of VB-QDs effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus, VB-QDs may serve as a possible alternative for therapeutic approaches for some cancer treatments. In summary, studies have shown that cancer cells are treated by the presence of VB-QDs nanoparticles based on analysis of cell apoptosis. |
| 关键词 | Quantum Dots Apoptosis Caspase 3 Verbascoside |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 关键词[WOS] | DAUNORUBICIN INDUCE APOPTOSIS ; FE3O4 NANOPARTICLES ; QUANTUM DOTS ; IN-VIVO ; PATHWAY ; CELLS ; THERAPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| WOS记录号 | WOS:000319747400009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/3938 |
| 专题 | 中国科学院西北高原生物研究所 |
| 通讯作者 | Zeng, X (reprint author), Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, State Key Lab Reprod Med, Dept Gynecol Endocrine, Nanjing 210029, Jiangsu, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.Key Lab Plateau Crop Germplasm Innovat & Utilizat, State Key Lab Breeding Base, Xining 810016, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, State Key Lab Reprod Med, Dept Gynecol Endocrine, Nanjing 210029, Jiangsu, Peoples R China 5.NanJing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,et al. EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE[J]. NANO,2013,8(3). |
| APA | Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,Zeng, Xin,Zhang, Gen,&Zeng, X .(2013).EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE.NANO,8(3). |
| MLA | Zhao, Xiao-Hui,et al."EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE".NANO 8.3(2013). |
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