Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau | |
Tong, Chao1,2,3; Tian, Fei1,2; Tang, Yongtao1,2,3; Feng, Chenguang1,2,3; Guan, Lihong4; Zhang, Cunfang1,2; Zhao, Kai1,2 | |
2016-03-01 | |
发表期刊 | FISH & SHELLFISH IMMUNOLOGY |
卷号 | 50页码:34-42 |
文章类型 | Article |
摘要 | Tibetan Plateau (TP) had experienced phased uplift, resulting in inhospitable environment of low temperature, hypoxia and high ultraviolet radiation for Tibetan wildlife. Many organisms can well adapt to TP, it is of ecological and evolutionary interest to untangle how organisms adapt to extreme environment on TP through evolution. Previous studies mainly focused on hypoxia and metabolism related genes, but we know little about the evolutionary history of immune genes in Tibetan wildlife. In this study, we first identified 10 interferon regulatory factor (IRF) genes from Tibetan naked carp Gymnocypris przewalskii. Within this gene family, IRF3, IRF5, IRF7 and IRF8 contained positive selection sites. Evidences indicated that positive selection may lead to IRF genes functional alternations, presumably driving genes towards adaptation to the environmental changes. Taken together, our results suggested 4 candidate genes as interesting targets for further experimental confirmation of their functional variations and contributions to high altitude adaptation in Tibet fish. (C) 2016 Elsevier Ltd. All rights reserved. |
关键词 | Highland Fish Gene Duplication Positive Selection Immunity Adaptation |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1016/j.fsi.2016.01.012 |
关键词[WOS] | HIGH-ALTITUDE ; MOLECULAR CHARACTERIZATION ; TRANSCRIPTION FACTORS ; EXPRESSION ANALYSIS ; MAXIMUM-LIKELIHOOD ; REVEALS ADAPTATION ; IRF FAMILY ; EVOLUTION ; FISH ; GENOME |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | Chinese Academy of Sciences (Key Innovation Plan)(KSCX2-YW-N-101 ; National Natural Science Foundation of China(30970341 ; West Light Foundation from the Chinese Academy of Sciences ; KSCX2-1W--N-004) ; 31172070 ; 31572258 ; 31500306) |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS类目 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS记录号 | WOS:000372693800006 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/5713 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Plateau Fish Evolutionary & Funct Genom, Xining 810001, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Xinxiang Med Univ, Dept Life Sci & Technol, Xinxiang 453003, Peoples R China |
推荐引用方式 GB/T 7714 | Tong, Chao,Tian, Fei,Tang, Yongtao,et al. Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau[J]. FISH & SHELLFISH IMMUNOLOGY,2016,50:34-42. |
APA | Tong, Chao.,Tian, Fei.,Tang, Yongtao.,Feng, Chenguang.,Guan, Lihong.,...&Zhao, Kai.(2016).Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau.FISH & SHELLFISH IMMUNOLOGY,50,34-42. |
MLA | Tong, Chao,et al."Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau".FISH & SHELLFISH IMMUNOLOGY 50(2016):34-42. |
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