The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice

doi:10.1016/j.yrtph.2016.03.017

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	The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice
	Wu, Qin 1; Li, Wen-Kai 1; Zhou, Zheng-Ping 2; Li, Ying-Ying 1; Xiong, Ting-Wan 1; Du, Yi-Zhi 3; Wei, Li-Xin 3; Liu, Jie 1
	2016-07-01
发表期刊	REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷号	78 页码:1-7
文章类型	Article
摘要	Zuotai is composed mainly of beta-HgS, while cinnabar mainly contains alpha-HgS. Both forms of HgS are used in traditional medicines and their safety is of concern. This study aimed to compare the hepatotoxicity potential of Zuotai and alpha-HgS with mercury chloride (HgCl2) and methylmercury (MeHg) in mice. Mice were orally administrated with Zuotai (30 mg/kg), alpha-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or CH3HgCl (3.1 mg/kg) for 7 days, and liver injury and gene expressions related to toxicity, inflammation and Nrf2 were examined. Animal body weights were decreased by HgCl2 and to a less extent by MeHg. HgCl2 and MeHg produced spotted hepatocyte swelling and inflammation, while such lesions are mild in Zuotai and HgS-treated mice. Liver Hg contents reached 45-70 ng/mg in HgCl2 and MeHg groups; but only 1-2 ng/mg in Zuotai and HgS groups. HgCl2 and MeHg increased the expression of liver injury biomarker genes metallothionein-1 (MT-1) and heme oxygenase-1 (HO-1); the inflammation biomarkers early growth response gene (Egr1), glutathione S-transferase (Gst-mu), chemokine (mKC) and microphage inflammatory protein (MIP-2), while these changes were insignificant in Zuotai and HgS groups. However, all mercury compounds were able to increase the Nrf2 pathway genes NAD(P)H:quinone oxidoreductase 1 (Nqo1) and Glutamate-cysteine ligase, catalytic subunit (Gclc). In conclusion, the Ti-betan medicine Zuotai and HgS are less hepatotoxic than HgCl2 and MeHg, and differ from HgCl2 and MeHg in hepatic Hg accumulation and toxicological responses. (C) 2016 Elsevier Inc. All rights reserved.
关键词	Zuotai Cinnabar Mercury Chloride Methylmercury Hepatotoxicity Electronmicrospy Gene Expression Nrf2
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.yrtph.2016.03.017
关键词[WOS]	AYURVEDIC MEDICINES ; OXIDATIVE STRESS ; MERCURY ; CINNABAR ; INDUCTION ; NRF2 ; RATS
收录类别	SCI
语种	英语
项目资助者	Key Laboratory Special Development Program of Qinghai Province(2014-Z-Y02) ; Chinese National Science Foundation(81374063 ; 81560682)
WOS研究方向	Legal Medicine ; Pharmacology & Pharmacy ; Toxicology
WOS类目	Medicine, Legal ; Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000377316000001
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/5762
专题	中国科学院西北高原生物研究所
作者单位	1.Zunyi Med Coll, Key Lab Basic Pharmacol, Minist Hlth, Zunyi, Peoples R China 2.Zunyi Med Coll, Med Res Ctr, Zunyi, Peoples R China 3.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining, Peoples R China
推荐引用方式 GB/T 7714	Wu, Qin,Li, Wen-Kai,Zhou, Zheng-Ping,et al. The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2016,78:1-7.
APA	Wu, Qin.,Li, Wen-Kai.,Zhou, Zheng-Ping.,Li, Ying-Ying.,Xiong, Ting-Wan.,...&Liu, Jie.(2016).The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice.REGULATORY TOXICOLOGY AND PHARMACOLOGY,78,1-7.
MLA	Wu, Qin,et al."The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice".REGULATORY TOXICOLOGY AND PHARMACOLOGY 78(2016):1-7.