Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis

NWIPB OpenIR

	Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
	Zheng, Wei ; Wang, Qilan ; Lu, Xiaohua ; Shi, Qiangqiang ; Zou, Junhui ; Tao, Yanduo ; Wang, Pu
	2016
发表期刊	MEDIATORS OF INFLAMMATION
摘要	Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/58326
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016.
APA	Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION.
MLA	Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016).