Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase

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	Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase
	Wen, Huaixiu; Tang, Bowen; Stewart, Alan J.; Tao, Yanduo; Shao, Yun; Cui, Yulei; Yue, Huilan; Pei, Jinjin; Liu, Zenggen; Mei, Lijuan; Yu, Ruitao; Jiang, Lei
	2018
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号	66 期号:6
摘要	Diabetes mellitus (DM) is a serious metabolic disorder, where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical erythritol is a C4 polyol approved by the U.S. Food and Drug Administration for use as a sweetener. Here, we examined a potential role for erythritol in the control of postprandial blood glucose levels in DM. An anti-postprandial hyperglycemia effect upon erythritol administration (500 mg kg(-1)) was demonstrated in alloxan-induced DM model mice by monitoring changes in blood glucose after intragastric administration of drugs and starch. We also found that erythritol most likely exerts its anti-postprandial hyperglycemic activities by inhibiting a-glucosidase in a competitive manner. This was supported by enzyme activity assays and molecular modeling experiments. In the latter experiments, it was possible to successfully dock erythritol into the catalytic pocket of a-glucosidase, with the resultant interaction likely driven by electrostatic interactions involving Asp215, Asp69, and Arg446 residues. This study suggests that erythritol may not only serve as a glucose substitute but also be a useful agent in the treatment of DM to help manage postprandial blood glucose levels.
关键词	diabetes mellitus postprandial blood glucose erythritol alpha-glucosidase competitive inhibition
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60020
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wen, Huaixiu,Tang, Bowen,Stewart, Alan J.,et al. Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(6).
APA	Wen, Huaixiu.,Tang, Bowen.,Stewart, Alan J..,Tao, Yanduo.,Shao, Yun.,...&Jiang, Lei.(2018).Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(6).
MLA	Wen, Huaixiu,et al."Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.6(2018).