Polydopamine nanospheres as high-affinity signal tag towards lateral flow immunoassay for sensitive furazolidone detection

NWIPB OpenIR

	Polydopamine nanospheres as high-affinity signal tag towards lateral flow immunoassay for sensitive furazolidone detection
	Liu, Sijie; Dou, Leina; Yao, Xiaolin; Zhang, Wentao; Zhao, Bingxin; Wang, Zonghan; Ji, Yanwei; Sun, Jing; Xu, Baocheng; Zhang, Daohong; Wang, Jianlong
	2020
发表期刊	FOOD CHEMISTRY
卷号	315
摘要	Currently, the low sensitivity and poor binding stability of detection probe prepared via electrostatic adsorption have become the dilemmas of colloidal gold-based lateral flow immunoassays (Au-LFIAs). In this connection, polydopamine nanospheres (PDA NPs) with an eminent covalent connectivity property were introduced as a promising substitute to improve the stability of probe and sensitivity of LFIA. Whereafter, the PDA NPs-based LFIA was applied for the monitoring of furazolidone (FZD) in food samples because of the potential carcinogenic/mutagenic effects to human of its metabolite (3-amino-2-oxazolidinone, AOZ). Compared with electrostatic adsorption, the binding stability of PDA NPs-based probes was superior. And, as expected, the PDA NPs-based LFIA biosensor exhibited higher sensitivity than that of the Au-LFIA with a detection limit of 3.5 ng mL(-1) for AOZ by naked-eye readout. Based on the significant enhanced binding stability and sensitivity, the PDA NPsbased LFIA is of certain spreading value for detecting other analytes.
关键词	Lateral flow immunoassay Furazolidone Polydopamine nanospheres Binding stability
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60312
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Sijie,Dou, Leina,Yao, Xiaolin,et al. Polydopamine nanospheres as high-affinity signal tag towards lateral flow immunoassay for sensitive furazolidone detection[J]. FOOD CHEMISTRY,2020,315.
APA	Liu, Sijie.,Dou, Leina.,Yao, Xiaolin.,Zhang, Wentao.,Zhao, Bingxin.,...&Wang, Jianlong.(2020).Polydopamine nanospheres as high-affinity signal tag towards lateral flow immunoassay for sensitive furazolidone detection.FOOD CHEMISTRY,315.
MLA	Liu, Sijie,et al."Polydopamine nanospheres as high-affinity signal tag towards lateral flow immunoassay for sensitive furazolidone detection".FOOD CHEMISTRY 315(2020).