Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Control of secondary structure and morphology of peptide-guanidiniocarbonylpyrrole conjugates by variation of the chain length | |
Liu, Xin; Wang, Kaiya; Externbrink, Marlen; Niemeyer, Jochen; Giese, Michael; Hu, Xiao-Yu | |
2020 | |
发表期刊 | CHINESE CHEMICAL LETTERS
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卷号 | 31期号:5 |
摘要 | Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of nanostructures. In this work, we present three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles, which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration regimes. The random coil conformation, alpha-helix, and beta-sheet are obtained for peptide 1, peptide 2, and peptide 3, respectively under neutral aqueous conditions. Furthermore, all peptide amphiphiles can aggregate to form nanoparticles at low concentrations. However, at high concentrations, peptide 1 self-assembles into left-handed twisted helical fibers, while longer bamboo-like morphology can be observed exclusively for peptide 2. For peptide 3, freshly prepared samples show uniform spherical morphology, whereas an obvious morphological transition from original nanoparticles to disordered fibers was realized after incubating for one week. These fascinating morphology changes were determined by the combination of circular dichroism, dynamic light scattering, transmission electron microscopy, atomic force microscopy, and theoretical calculations. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
关键词 | Peptide amphiphiles Secondary structures Supramolecular self-assembly Nanostructures pH-responsiveness |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/60345 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Liu, Xin,Wang, Kaiya,Externbrink, Marlen,et al. Control of secondary structure and morphology of peptide-guanidiniocarbonylpyrrole conjugates by variation of the chain length[J]. CHINESE CHEMICAL LETTERS,2020,31(5). |
APA | Liu, Xin,Wang, Kaiya,Externbrink, Marlen,Niemeyer, Jochen,Giese, Michael,&Hu, Xiao-Yu.(2020).Control of secondary structure and morphology of peptide-guanidiniocarbonylpyrrole conjugates by variation of the chain length.CHINESE CHEMICAL LETTERS,31(5). |
MLA | Liu, Xin,et al."Control of secondary structure and morphology of peptide-guanidiniocarbonylpyrrole conjugates by variation of the chain length".CHINESE CHEMICAL LETTERS 31.5(2020). |
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