Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function

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	Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function
	Tie, Fangfang; Wang, Jifei; Liang, Yuexin; Zhu, Shujun; Wang, Zhenhua; Li, Gang; Wang, Honglun
	2020
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	21 期号:6
摘要	Proanthocyanidins are the major active compounds extracted from Iris lactea Pall. var. Chinensis (Fisch.) Koidz (I. lactea). Proanthocyanidins exhibit a variety of pharmacological activities such as anti-oxidation, anti-inflammation, anti-tumor, and lowering blood lipids. However, the underlying mechanism of its regulating effect on lipid metabolism in diabetic conditions remains unclear. The present study investigated the effects of I. lactea-derived proanthocyanidins on lipid metabolism in mice of type 2 diabetes mellitus (T2DM). Results demonstrated a beneficial effect of total proanthocyanidins on dysregulated lipid metabolism and hepatic steatosis in high-fat-diet/streptozocin (STZ)-induced T2DM. To identify the mechanisms, six flavan-3-ols were isolated from proanthocyanidins of I. lacteal and their effects on adipogenesis and dexamethasone (Dex)-induced mitochondrial dysfunctions in 3T3-L1 adipocytes were determined. In vitro studies showed flavan-3-ols inhibited adipogenesis and restored mitochondrial function after Dex-induced insulin resistance, being suggested by increased mitochondrial membrane potential, intracellular ATP contents, mitochondrial mass and mitochondrial biogenesis, and reduced reactive oxygen species. Among the six flavan-3-ols, procyanidin B3 and procyanidin B1 exhibited the strongest effects. Our study suggests potential of proanthocyanidins as therapeutic target for diabetes.
关键词	proanthocyanidins flavan-3-ols lipid metabolism T2DM 3T3-L1 adipocytes mitochondrial function
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60391
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Tie, Fangfang,Wang, Jifei,Liang, Yuexin,et al. Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(6).
APA	Tie, Fangfang.,Wang, Jifei.,Liang, Yuexin.,Zhu, Shujun.,Wang, Zhenhua.,...&Wang, Honglun.(2020).Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(6).
MLA	Tie, Fangfang,et al."Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.6(2020).