Sulphonate functionalized covalent organic framework-based magnetic sorbent for effective solid phase extraction and determination of fluoroquinolones

NWIPB OpenIR

	Sulphonate functionalized covalent organic framework-based magnetic sorbent for effective solid phase extraction and determination of fluoroquinolones
	Wen, Aying; Li, Guoliang; Wu, Di; Yu, Yanxin; Yang, Yan; Hu, Na; Wang, Honglun; Chen, Jian; Wu, Yongning
	2020
发表期刊	JOURNAL OF CHROMATOGRAPHY A
卷号	1612
摘要	Most of the reported covalent organic frameworks (COFs) are hydrophobic, limiting their adsorption application in sample pretreatment field. In this work, sulphonate functionalized magnetic covalent organic frameworks (COFs) composites were first synthesized by loading gold nanoparticles on Fe3O4@COF(TpBD) surface and then functionalized by sodium 3-mercaptopropanesulphonate immobilization via Au-S bonding formation (denoted as Fe3O4@COF(TpBD)@Au-MPS nanocomposites), which were further utilized as adsorbents for magnetic solid-phase extraction (MSPE) of fluoroquinolones. Compared with Fe3O4@COF(TpBD), the composites exhibited higher affinity to fluoroquinolones. Under optimized conditions, the developed MSPE method coupled with HPLC-MS/MS showed good linearity (R-2 >0.9989) and yielded low limits of detection (0.1-1.0 mu g kg(-1)) for fluoroquinolones. Moreover, the proposed method was successfully applied to extract fluoroquinolones from spiked meats (pork, chicken and bovine). The satisfactory recoveries were in the range of 82-110.2% with the relative standard deviations (RSDs) lower than 7.7%. These results indicated that the Fe3O4@COF(TpBD)@Au-MPS is a promising magnetic adsorbent for trace fluoroquinolones determination in meat samples. This work not only provided a facile strategy for COF functionalization, but also developed an efficient method for detecting fluoroquinolones in foodstuffs. (C) 2019 Elsevier B.V. All rights reserved.
关键词	Fluoroquinolones Covalent organic frameworks Magnetic solid phase extraction Food analysis HPLC-MS/MS Meat samples
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60414
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wen, Aying,Li, Guoliang,Wu, Di,et al. Sulphonate functionalized covalent organic framework-based magnetic sorbent for effective solid phase extraction and determination of fluoroquinolones[J]. JOURNAL OF CHROMATOGRAPHY A,2020,1612.
APA	Wen, Aying.,Li, Guoliang.,Wu, Di.,Yu, Yanxin.,Yang, Yan.,...&Wu, Yongning.(2020).Sulphonate functionalized covalent organic framework-based magnetic sorbent for effective solid phase extraction and determination of fluoroquinolones.JOURNAL OF CHROMATOGRAPHY A,1612.
MLA	Wen, Aying,et al."Sulphonate functionalized covalent organic framework-based magnetic sorbent for effective solid phase extraction and determination of fluoroquinolones".JOURNAL OF CHROMATOGRAPHY A 1612(2020).