Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay

NWIPB OpenIR

	Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay
	Yin, XC; Dou, LN; Yao, XL; Liu, SJ; Zhang, L; Zhao, M; Su, LH; Sun, J; Wang, JL; Zhang, DH
	2021
发表期刊	FOOD CHEMISTRY
卷号	367
摘要	Creating universal signal labels from fundamental building blocks with excellent biocompatibility and wellcontrolled size/uniformity simultaneously for immunochromatographic assay (ICA) is highly desired but extremely challenging. Here, a nano-signal label strategy was reported, in which the amino-terminated zirconium MOFs (NU66) are adopted to construct powerful matrix materials and gold nanoparticles (AuNPs) act as the linker between metal-organic frameworks (MOFs) and antibodies. Particularly, AuNPs were immobilized directly on the surface of NU66, giving NU66 excellent biocompatibility with bright color signal labels and improving the salt ion stability of AuNPs. As a proof of concept, the furazolidone residues was monitored by the developed NU66@AuNPs-ICA in food samples (pork, shrimp and eggs). With 3-[(4-carboxyphenyl) monomethyl] amino-2oxazolidinone (CPAOZ) as analyte target, the visual limit of detection (vLOD) and cut-off level were 0.6 ng/mL and 3.0 ng/mL, respectively. This work may open a new avenue for the application of MOFs in immunochromatography assays.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61371
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yin, XC,Dou, LN,Yao, XL,et al. Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay[J]. FOOD CHEMISTRY,2021,367.
APA	Yin, XC.,Dou, LN.,Yao, XL.,Liu, SJ.,Zhang, L.,...&Zhang, DH.(2021).Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay.FOOD CHEMISTRY,367.
MLA	Yin, XC,et al."Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay".FOOD CHEMISTRY 367(2021).