A new isocoumarin from the aerial parts of Aconitum gymnandrum

doi:10.1080/14786419.2015.1137574

NWIPB OpenIR

	A new isocoumarin from the aerial parts of Aconitum gymnandrum
	Zhao, Jian-Qiang 1,2,5; Wang, Yan-Ming 3,4,5; Wang, Shuo 1,2; Dang, Jun 1,2; Shi, Yan-Ping 3,4; Mei, Li-Juan 1,2; Tao, Yan-Duo 1,2
	2016
发表期刊	NATURAL PRODUCT RESEARCH
卷号	30 期号:15 页码:1746-1752
文章类型	Article
摘要	A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1-5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2.
关键词	Aconitum Gymnandrum Isocourmain Cytotoxic Activity
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI	10.1080/14786419.2015.1137574
关键词[WOS]	QINGHAI-TIBETAN PLATEAU ; AGRIMONIA-PILOSA ; ALKALOIDS
收录类别	SCI
语种	英语
项目资助者	Significant Science & Technological Project of Qinghai Province(2014-GX-A3A)
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000382561200011
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6433
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res CAS, Xinning, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Qinghai Prov, Xinning, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jian-Qiang,Wang, Yan-Ming,Wang, Shuo,et al. A new isocoumarin from the aerial parts of Aconitum gymnandrum[J]. NATURAL PRODUCT RESEARCH,2016,30(15):1746-1752.
APA	Zhao, Jian-Qiang.,Wang, Yan-Ming.,Wang, Shuo.,Dang, Jun.,Shi, Yan-Ping.,...&Tao, Yan-Duo.(2016).A new isocoumarin from the aerial parts of Aconitum gymnandrum.NATURAL PRODUCT RESEARCH,30(15),1746-1752.
MLA	Zhao, Jian-Qiang,et al."A new isocoumarin from the aerial parts of Aconitum gymnandrum".NATURAL PRODUCT RESEARCH 30.15(2016):1746-1752.