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Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
Zheng, Wei1,2; Wang, Qilan3; Lu, Xiaohua1; Shi, Qiangqiang3; Zou, Junhui1; Tao, Yanduo3; Wang, Pu1
2016
发表期刊MEDIATORS OF INFLAMMATION
文章类型Article
摘要Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1155/2016/2684321
关键词[WOS]SYNERGISTIC LIVER-INJURY ; SUPPRESSOR-CELLS ; BACTERIAL LIPOPOLYSACCHARIDE ; KUPFFER CELLS ; CANCER ; MONOCROTALINE ; INFLAMMATION ; INFECTION ; CYTOKINES ; EXPOSURE
收录类别SCI
语种英语
项目资助者Key Project of Science and Technology of Qinghai(2014-GX-220) ; Project of Science and Technology of Guangdong(2013B010404039) ; State Key Laboratory of Veterinary Etiological Biology(SKLVEB2015KFKT004) ; Shenzhen Science and Technology Program(JCYJ20130401170306850 ; Shenzhen Peacock Next Generation Monoclonal Antibody Drug Research and Development Program(KQTD201210) ; JCYJ20150401145529036 ; JCYJ20150521094519486)
WOS研究方向Cell Biology ; Immunology
WOS类目Cell Biology ; Immunology
WOS记录号WOS:000381138700001
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/6440
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
2.Acad Mil Med Sci, Inst Mil Vet Med, Changchun 130122, Peoples R China
3.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Peoples R China
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GB/T 7714
Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016.
APA Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION.
MLA Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016).
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