Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis | |
Zheng, Wei1,2; Wang, Qilan3; Lu, Xiaohua1; Shi, Qiangqiang3; Zou, Junhui1; Tao, Yanduo3; Wang, Pu1 | |
2016 | |
发表期刊 | MEDIATORS OF INFLAMMATION |
文章类型 | Article |
摘要 | Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1155/2016/2684321 |
关键词[WOS] | SYNERGISTIC LIVER-INJURY ; SUPPRESSOR-CELLS ; BACTERIAL LIPOPOLYSACCHARIDE ; KUPFFER CELLS ; CANCER ; MONOCROTALINE ; INFLAMMATION ; INFECTION ; CYTOKINES ; EXPOSURE |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | Key Project of Science and Technology of Qinghai(2014-GX-220) ; Project of Science and Technology of Guangdong(2013B010404039) ; State Key Laboratory of Veterinary Etiological Biology(SKLVEB2015KFKT004) ; Shenzhen Science and Technology Program(JCYJ20130401170306850 ; Shenzhen Peacock Next Generation Monoclonal Antibody Drug Research and Development Program(KQTD201210) ; JCYJ20150401145529036 ; JCYJ20150521094519486) |
WOS研究方向 | Cell Biology ; Immunology |
WOS类目 | Cell Biology ; Immunology |
WOS记录号 | WOS:000381138700001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/6440 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 2.Acad Mil Med Sci, Inst Mil Vet Med, Changchun 130122, Peoples R China 3.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Peoples R China |
推荐引用方式 GB/T 7714 | Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016. |
APA | Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION. |
MLA | Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论