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Separation of three anthraquinone glycosides including two isomers by preparative high-performance liquid chromatography and high-speed countercurrent chromatography from Rheum tanguticum Maxim. ex Balf
Chen, Tao1,2; Li, Hongmei1,2,3; Zou, Denglang1,2,3; Liu, Yongling1,2; Chen, Chen1,2; Zhou, Guoying1,2; Li, Yulin1,2
2016-08-01
Source PublicationJOURNAL OF SEPARATION SCIENCE
Volume39Issue:16Pages:3105-3112
SubtypeArticle
AbstractAnthraquinone glycosides, such as chrysophanol 1-O--d-glucoside, chrysophanol 8-O--d-glucoside, and physion 8-O--d-glucoside, are the accepted important active components of Rheum tanguticum Maxim. ex Balf. due to their pharmacological properties: antifungal, antimicrobial, cytotoxic, and antioxidant activities. However, an effective method for the separation of the above-mentioned anthraquinone glycosides from this herb is not currently available. Especially, greater difficulty existed in the separation of the two isomers chrysophanol 1-O--d-glucoside and chrysophanol 8-O--d-glucoside. This study demonstrated an efficient strategy based on preparative high-performance liquid chromatography and high-speed countercurrent chromatography for the separation of the above-mentioned anthraquinone glycosides from Rheum tanguticum Maxim.ex Balf.
KeywordAnthraquinone Glycosides High-speed Countercurrent Chromatography Isomers Preparative High-performance Liquid Chromatography Rheum Tanguticum Maxim Ex Balf
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/jssc.201600487
WOS KeywordMASS-SPECTROMETRY ; MACROPOROUS RESIN ; RAPID ENRICHMENT ; SCALE-UP ; PURIFICATION ; HPLC ; RHUBARB ; CONSTITUENTS ; EXTRACTION ; EMODI
Indexed BySCI
Language英语
Funding OrganizationStrategic Pilot Science and Technology Project of CAS(XDA12050304) ; General Program of Natural Science Foundation of Qinghai Province(2015-ZJ-908) ; Science and Technology Support Program of Qinghai Province(2015-NS-115) ; Instrument Function Development Project of CAS(2017g107)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000383361800002
Citation statistics
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6450
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chen, Tao,Li, Hongmei,Zou, Denglang,et al. Separation of three anthraquinone glycosides including two isomers by preparative high-performance liquid chromatography and high-speed countercurrent chromatography from Rheum tanguticum Maxim. ex Balf[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(16):3105-3112.
APA Chen, Tao.,Li, Hongmei.,Zou, Denglang.,Liu, Yongling.,Chen, Chen.,...&Li, Yulin.(2016).Separation of three anthraquinone glycosides including two isomers by preparative high-performance liquid chromatography and high-speed countercurrent chromatography from Rheum tanguticum Maxim. ex Balf.JOURNAL OF SEPARATION SCIENCE,39(16),3105-3112.
MLA Chen, Tao,et al."Separation of three anthraquinone glycosides including two isomers by preparative high-performance liquid chromatography and high-speed countercurrent chromatography from Rheum tanguticum Maxim. ex Balf".JOURNAL OF SEPARATION SCIENCE 39.16(2016):3105-3112.
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