Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties

doi:10.1038/srep32679

NWIPB OpenIR

	Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties
	Wang, Yongcui 1; Fang, Jianwen 2; Chen, Shilong1
	2016-09-20
发表期刊	SCIENTIFIC REPORTS
卷号	6
文章类型	Article
摘要	Accurately predicting the response of a cancer patient to a therapeutic agent is a core goal of precision medicine. Existing approaches were mainly relied primarily on genomic alterations in cancer cells that have been treated with different drugs. Here we focus on predicting drug response based on integration of the heterogeneously pharmacogenomics data from both cell and drug sides. Through a systematical approach, named as PDRCC (Predict Drug Response in Cancer Cells), the cancer genomic alterations and compound chemical and therapeutic properties were incorporated to determine the chemotherapeutic response in cancer patients. Using the Cancer Cell Line Encyclopedia (CCLE) study as the benchmark dataset, all pharmacogenomics data exhibited their roles in inferring the relationships between cancer cells and drugs. When integrating both genomic resources and compound information, the prediction coverage was significantly increased. The validity of PDRCC was also supported by its effective in uncovering the unknown cell-drug associations with database and literature evidences. It set the stage for clinical testing of novel therapeutic strategies, such as the sensitive association between cancer cell 'A549_LUNG' and compound 'Topotecan'. In conclusion, PDRCC offers the possibility for faster, safer, and cheaper the development of novel anti-cancer therapeutics in the early-stage clinical trails.
WOS标题词	Science & Technology
DOI	10.1038/srep32679
关键词[WOS]	ADVANCED PANCREATIC-CANCER ; GENE-EXPRESSION LEVELS ; LUNG-CANCER ; PROTEIN FUNCTION ; SENSITIVITY ; PREDICTION ; IRINOTECAN ; IDENTIFICATION ; TOPOTECAN ; SEQUENCE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(11671396 ; National Science Foundation of China for Basic Research Program(2015FY110500) ; Qinghai Sciences and Technology Department for Basic Research Program(2016-ZJ-744) ; 11371365 ; 31270270)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000383490100001
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6455
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.NCI, Biometr Res Branch, Div Canc Treatment & Diag, Rockville, MD 20850 USA
推荐引用方式 GB/T 7714	Wang, Yongcui,Fang, Jianwen,Chen, Shilong. Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties[J]. SCIENTIFIC REPORTS,2016,6.
APA	Wang, Yongcui,Fang, Jianwen,&Chen, Shilong.(2016).Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties.SCIENTIFIC REPORTS,6.
MLA	Wang, Yongcui,et al."Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties".SCIENTIFIC REPORTS 6(2016).