Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia

doi:10.5582/bst.2016.01056

NWIPB OpenIR

	Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia
	Yang, Fang 1,2,3; Suo, Yourui 1,4; Chen, Dongli 5; Tong, Li 2
	2016-06-01
发表期刊	BIOSCIENCE TRENDS
卷号	10 期号:3 页码:188-196
文章类型	Article
摘要	Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-alpha and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.
关键词	Vascular Endothelial Dysfunction Polyphenol Sea Buckthorn Berries Hyperlipidemia Protection
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.5582/bst.2016.01056
关键词[WOS]	HIPPOPHAE-RHAMNOIDES L. ; LOW-DENSITY-LIPOPROTEIN ; CORONARY HEART-DISEASE ; NLRP3 INFLAMMASOME ; OXIDATIVE STRESS ; RISK-FACTORS ; IN-VITRO ; FLAVONOIDS ; ANTIOXIDANT ; ACTIVATION
收录类别	SCI
语种	英语
项目资助者	Special Fund for the International Scientific and Technological Cooperation Program(2014DFA31020)
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000379253700004
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6469
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, 23 Xinning Rd, Xining 810001, Qinghai, Peoples R China 2.Qinghai Univ, Coll Med, Xining, Qinghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Qinghai Univ, Qinghai Acad Agr & Forestry Sci, Xining, Qinghai, Peoples R China 5.AA Pharma Inc, Boston, MA USA
推荐引用方式 GB/T 7714	Yang, Fang,Suo, Yourui,Chen, Dongli,et al. Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia[J]. BIOSCIENCE TRENDS,2016,10(3):188-196.
APA	Yang, Fang,Suo, Yourui,Chen, Dongli,&Tong, Li.(2016).Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia.BIOSCIENCE TRENDS,10(3),188-196.
MLA	Yang, Fang,et al."Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia".BIOSCIENCE TRENDS 10.3(2016):188-196.