Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth

doi:10.1166/jnn.2016.11357

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	Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth
	Ma, Zhinan 1; Zhao, Xiaohui 2; Jiang, Caiyun 3; Yu, Jun 4; Wu, Jiangping 5; Zeng, Xin 6
	2016-07-01
发表期刊	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号	16 期号:7 页码:7118-7124
文章类型	Article
摘要	In the present work, a new system of drug delivery to enhance the chemotherapy efficiency for cancer was established. Novel core-shell structures were presented here, which were consisted of poly (N-isopropyl acrylamide) (PNIPAM) microspheres as cores and gold as shells. Next, the chemotherapeutic agent Verbascoside (VB) was combined with PNIPAM/gold nanoshells (GNSs) structures (PMS) for inducing apoptosis in drug resistant leukemia cells (K562/A02; KA). The exploration on xenografted tumors in KA nude mice indicated that anticancer drug loaded on PNIPAM/GNSs was an efficient drug delivery vector. It induced the apoptosis of KA cells in vitro and in vivo. Apoptotic staining and DNA fragmentation further demonstrated that the apoptosis rate increased via the treatment of PMS together with VB (VB-PMS) in KA cells, compared with PMS or VB treatment alone. Moreover, VB-PMS activated the expression of apoptosis-related caspase proteins in KA cells. In summary, a novel drug delivery system has been established, and has further been proved that the combination of VB and PMS could improve therapeutic efficacy for leukemia.
关键词	Nanoshells Apoptosis Caspase Verbascoside
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1166/jnn.2016.11357
关键词[WOS]	PHOTOTHERMAL THERAPY ; FE3O4 NANOPARTICLES ; CANCER-CELLS ; MICELLES
收录类别	SCI
语种	英语
项目资助者	NSFC(31201003 ; state key laboratory of bioelectronics of southeast university(2012F12 ; Natural Science Foundation of Jiangsu Province(BK20130892) ; 81301305) ; 2012F13)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000387100400071
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6667
专题	中国科学院西北高原生物研究所
作者单位	1.Yangzhou Med Univ, Yangzhou Maternal & Child Hlth Hosp, Dept Obstet & Gynecol, Yangzhou 225000, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 3.Jiangsu Engn & Res Ctr Food Safety, Jiangsu Inst Commerce, Dept Engn & Technol, Nanjing 211168, Jiangsu, Peoples R China 4.Hunan Univ Technol, Hunan Key Lab Green Packaging & Applicat Biol Nan, Zhuzhou 412007, Peoples R China 5.Nanjing Matern & Child Hlth Care Hosp, Womens Hlth Div, Nanjing 210029, Jiangsu, Peoples R China 6.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,et al. Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7118-7124.
APA	Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,Yu, Jun,Wu, Jiangping,&Zeng, Xin.(2016).Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7118-7124.
MLA	Ma, Zhinan,et al."Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7118-7124.