Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Excipient-Assisted Vinpocetine Nanoparticles: Experiments and Molecular Dynamic Simulations | |
Li, Cai-Xia1,2; Wang, Hao-Bo1; Oppong, Daniel1; Wang, Jie-Xin1; Chen, Jian-Feng1; Le, Yuan1 | |
2014-11-01 | |
发表期刊 | MOLECULAR PHARMACEUTICS
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卷号 | 11期号:11页码:4023-4035 |
文章类型 | Article |
摘要 | Hydrophilic excipients can be used to increase the solubility and bioavailability of poorly soluble drugs. In this work, the conventional water-soluble pharmaceutical excipients hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone (PVP), and lactose (LAC) were used as solid supports to prevent drug nanoparticles from aggregation and enhance drug dissolution. Excipient-assisted vinpocetine (VIN) nanoparticles were prepared by reactive precipitation. The analysis results indicated that HPMC was a suitable excipient to prepare VIN nanoparticles. VIN/HPMC nanoparticles had a mean size of 130 nm within a narrow distribution. The dissolution rate of VIN nanoparticles was significantly faster than those of a physical mixture of VIN/HPMC and raw VIN. VIN/HPMC nanoparticles had a higher dissolution profile than VIN/PVP and VIN/LAC nanoparticles. Besides, molecular dynamics (MD) simulation was applied to investigate the molecular interactions between VIN and excipients. The calculated results revealed that VIN interacted with excipients by Coulomb and Lennard-Jones (LJ) interactions. Few hydrogen bonds were formed between VIN and excipients. The HPMC affording smaller particle size may be a result of the stronger interactions between VIN and HPMC (mainly LJ interaction) and the property of HPMC. These characteristics may greatly influence the adsorption behavior and may be the crucial parameter for the better performance of HPMC. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | WATER-SOLUBLE POLYMERS ; PARTICLE MESH EWALD ; REACTIVE PRECIPITATION ; PHYSICOCHEMICAL PROPERTIES ; ANTISOLVENT PRECIPITATION ; ORAL BIOAVAILABILITY ; SALBUTAMOL SULFATE ; CONTROLLED-RELEASE ; DELIVERY SYSTEMS ; CRYSTAL-GROWTH |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000344307700028 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/6842 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Cai-Xia,Wang, Hao-Bo,Oppong, Daniel,et al. Excipient-Assisted Vinpocetine Nanoparticles: Experiments and Molecular Dynamic Simulations[J]. MOLECULAR PHARMACEUTICS,2014,11(11):4023-4035. |
APA | Li, Cai-Xia,Wang, Hao-Bo,Oppong, Daniel,Wang, Jie-Xin,Chen, Jian-Feng,&Le, Yuan.(2014).Excipient-Assisted Vinpocetine Nanoparticles: Experiments and Molecular Dynamic Simulations.MOLECULAR PHARMACEUTICS,11(11),4023-4035. |
MLA | Li, Cai-Xia,et al."Excipient-Assisted Vinpocetine Nanoparticles: Experiments and Molecular Dynamic Simulations".MOLECULAR PHARMACEUTICS 11.11(2014):4023-4035. |
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