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Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity
Chen, Tao1,2; Li, Hongmei1,2,3; Chen, Chen1,2; Wei, Lixin1,2; Li, Yulin1,2
2017-07-01
Source PublicationJOURNAL OF CHROMATOGRAPHIC SCIENCE
Volume55Issue:6Pages:638-644
SubtypeArticle
AbstractLarge-scale preparation and alpha-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro alpha-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose. The study showed that swertioside had potential use as an anti-diabetic agent.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1093/chromsci/bmx020
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; COUNTER-CURRENT CHROMATOGRAPHY ; IONIC LIQUIDS ; PURIFICATION ; SEPARATION ; HPLC ; EXTRACT ; ROOT ; POLYSACCHARIDES ; COMBINATION
Indexed BySCI
Language英语
Funding Organization"Personalized Medicines-Molecular Signaturebased Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12050304) ; Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources and General Program of Natural Science Foundation of Qinghai Province(2015-ZJ-908)
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:000404619700007
Citation statistics
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/7079
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xinning Rd, Xining 810008, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, 23 Xinning Rd, Xining 810008, Peoples R China
3.Univ Chinese Acad Sci, Savaid Med Sch, 19 Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Tao,Li, Hongmei,Chen, Chen,et al. Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE,2017,55(6):638-644.
APA Chen, Tao,Li, Hongmei,Chen, Chen,Wei, Lixin,&Li, Yulin.(2017).Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity.JOURNAL OF CHROMATOGRAPHIC SCIENCE,55(6),638-644.
MLA Chen, Tao,et al."Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its alpha-Glucosidase Inhibitory Activity".JOURNAL OF CHROMATOGRAPHIC SCIENCE 55.6(2017):638-644.
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