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Separation of six xanthones from Swertia franchetiana by high-speed countercurrent chromatography
Li, Hongmei1,2; Chen, Tao1; Sun, Jing1; Wang, Weiqing3; Li, Yulin1
2017-06-01
Source PublicationJOURNAL OF SEPARATION SCIENCE
Volume40Issue:11Pages:2515-2521
SubtypeArticle
AbstractIn our present study, two groups of xanthones isomers (1-hydroxy-3,5,8-trimethoxyxanthone and 1-hydroxy-3,7,8-trimethoxyxanthone; 1,8-dihydroxy-3,7-dimethoxyxanthone and 1,8-dihydroxy-3,5-dimethanolxanthone) and other two xanthones (3-methoxy-1,5,8-trihydroxyxanthone and 3,5-dimethoxy-1-hydroxyxanthone) were separated from Swertia franchetiana. First, a solvent system composed of petroleum ether/methanol/water (2:1:0.6, v/v) was developed for the liquid-liquid extraction of these xanthones from the crude extract. Then, an efficient method was established for the one-step separation of these six xanthones by high-speed countercurrent chromatography using n-hexane/ethyl acetate/methanol/ethanol/water (HEMEW; 6:4:4:2:4, v/v) as the solvent system. The results showed that liquid-liquid extraction could be well developed for efficient enrichment of target compounds. Additionally, high-speed countercurrent chromatography could be a powerful technology for separation xanthones isomers. It was found ethanol could be a good methanol substitute when the HEMEW system could not provide good separation factors.
KeywordCountercurrent Chromatography Isomers Swertia Franchetiana Xanthones
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/jssc.201601134
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; 3 ANTHRAQUINONE GLYCOSIDES ; RHEUM-TANGUTICUM ; ULTRAFILTRATION-HPLC ; MACROPOROUS RESIN ; RAPID ENRICHMENT ; PURIFICATION ; EXTRACTION ; IDENTIFICATION ; INHIBITORS
Indexed BySCI
Language英语
Funding Organization"Personalized Medicines-Molecular Signature-based Drug Discovery and Development," Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12050304) ; National Natural Science Foundation of China(81403051) ; Instrument Function Development Project of CAS(2017g107)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000403461500023
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/7085
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China
3.Qinghai Prov Prod Qual Supervis & Inspect Ctr, Xining, Peoples R China
Recommended Citation
GB/T 7714
Li, Hongmei,Chen, Tao,Sun, Jing,et al. Separation of six xanthones from Swertia franchetiana by high-speed countercurrent chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2017,40(11):2515-2521.
APA Li, Hongmei,Chen, Tao,Sun, Jing,Wang, Weiqing,&Li, Yulin.(2017).Separation of six xanthones from Swertia franchetiana by high-speed countercurrent chromatography.JOURNAL OF SEPARATION SCIENCE,40(11),2515-2521.
MLA Li, Hongmei,et al."Separation of six xanthones from Swertia franchetiana by high-speed countercurrent chromatography".JOURNAL OF SEPARATION SCIENCE 40.11(2017):2515-2521.
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