Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim
Yuan Xiang1,2; Zhao Jing3; Wang Haixia1; Yu Ruitao1; Wen Huaixiu1,2; Liu Zenggen1; Mei Lijuan1; Wang Yiping3; Tao Yanduo1
AbstractThe aim of the present study was to evaluate the antiproliferative effect of phenylpropanoids isolated from the n-BuOH-soluble fraction of an ethanolic extract of Lagotis brevituba Maxim. The phenylpropanoids were identified as echinacoside, lagotioside, glucopyranosyl(1-6)martynoside, plantamoside, and verbascoside. Three of the compounds, lagotioside, glucopyranosyl(1-6)martynoside, and plantamoside, were isolated from L. brevituba for the first time. The antiproliferative activity of the isolates was evaluated in human gastric carcinoma (MGC-803), human colorectal carcinoma (HCT116), human hepatocellar carcinoma (HepG2), and human lung cancer (HCT116) cells using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Plantamoside showed promising activity against MGC-803 cells, with a half maximal inhibitory concentration value of 37.09 mu M. The mechanism of the pro-apoptosis effect of plantamoside was then evaluated in MGC-803 cells. Changes in cell morphology, including disorganization of the architecture of actin microfilaments and formation of apoptotic bodies, together with cell cycle arrest in G2/M phases, were observed after treatment of plantamoside. The antiproliferative and pro-apoptotic effects were associated with a decrease in the ratio of Bcl-2/Bax and reduced mitochondrial membrane potential, which was accompanied by the release of reactive oxygen species and Ca2+ into the cytoplasm. Taken together, the results indicated that plantamoside promotes apoptosis via a mitochondria-dependent mechanism. Copyright (c) 2017 John Wiley & Sons, Ltd.
KeywordPhenylpropanoids Lagotis Brevituba Maxim Antiproliferative Plantamoside
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationChinese Academy of Sciences(ZSTH-027) ; Major Science and Technology Projects in Qinghai Province(2014-GX-A3A-01) ; Qinghai Association for Science and Technology(2017KX05)
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000412164200005
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang Yiping; Tao Yanduo
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100000, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Yuan Xiang,Zhao Jing,Wang Haixia,et al. Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim[J]. PHYTOTHERAPY RESEARCH,2017,31(10):1509-1520.
APA Yuan Xiang.,Zhao Jing.,Wang Haixia.,Yu Ruitao.,Wen Huaixiu.,...&Tao Yanduo.(2017).Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim.PHYTOTHERAPY RESEARCH,31(10),1509-1520.
MLA Yuan Xiang,et al."Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim".PHYTOTHERAPY RESEARCH 31.10(2017):1509-1520.
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