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Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles
Qu, Fei1,2; Liu, Yanqun1,2; Lao, Haili3; Wang, Yaping1,2; You, Jinmao1,2,4
2017-10-07
发表期刊NEW JOURNAL OF CHEMISTRY
ISSN1144-0546
卷号41期号:19页码:10592-10597
文章类型Article
摘要Herein, a new colorimetric strategy based on polymer nanoparticles (PNPs) and Au nanoparticles (AuNPs) is developed to detect heparin (Hep). The cationic PNPs can directly induce the aggregation of AuNPs, which are stabilized by negatively charged coating of citrate ions, and hence the absorption peak of AuNPs moves to 675 nm corresponding with a color change from wine red to blue. However, the negatively charged Hep competes with AuNPs and binds to PNPs, hindering the interaction between PNPs and AuNPs. As a result, the absorption band of AuNPs blue shifts and the color turns to red again. The reaction can be completed within 10 min, and the color variation produced by 150 nM of Hep can be distinguished by the naked eye. In addition, this strategy also shows good selectivity and sensitivity, and the linear range of Hep is from 10 to 400 nM with detection limit of 2.5 nM. Finally, this colorimetric assay has been applied to measure Hep in Hep sodium injection and human serum samples with satisfactory recoveries.
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c7nj02381b
关键词[WOS]PEROXIDASE-LIKE ACTIVITY ; INDUCED THROMBOCYTOPENIA ; THROMBOPLASTIN TIME ; INDUCED EMISSION ; QUANTUM DOTS ; SULFATE ; ASSAY ; NANOCOMPOSITES ; NANOCLUSTERS ; SURFACTANT
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China (Youth Fund Project)(21405093) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000411768600011
出版者ROYAL SOC CHEMISTRY
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/9813
专题中国科学院西北高原生物研究所
通讯作者Qu, Fei; You, Jinmao
作者单位1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Binzhou Cent Hosp, Binzhou Med Coll, Dept Clin Lab, Binzhou 256600, Shandong, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China
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GB/T 7714
Qu, Fei,Liu, Yanqun,Lao, Haili,et al. Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles[J]. NEW JOURNAL OF CHEMISTRY,2017,41(19):10592-10597.
APA Qu, Fei,Liu, Yanqun,Lao, Haili,Wang, Yaping,&You, Jinmao.(2017).Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles.NEW JOURNAL OF CHEMISTRY,41(19),10592-10597.
MLA Qu, Fei,et al."Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles".NEW JOURNAL OF CHEMISTRY 41.19(2017):10592-10597.
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