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Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles
Qu, Fei1,2; Liu, Yanqun1,2; Lao, Haili3; Wang, Yaping1,2; You, Jinmao1,2,4
2017-10-07
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume41Issue:19Pages:10592-10597
SubtypeArticle
AbstractHerein, a new colorimetric strategy based on polymer nanoparticles (PNPs) and Au nanoparticles (AuNPs) is developed to detect heparin (Hep). The cationic PNPs can directly induce the aggregation of AuNPs, which are stabilized by negatively charged coating of citrate ions, and hence the absorption peak of AuNPs moves to 675 nm corresponding with a color change from wine red to blue. However, the negatively charged Hep competes with AuNPs and binds to PNPs, hindering the interaction between PNPs and AuNPs. As a result, the absorption band of AuNPs blue shifts and the color turns to red again. The reaction can be completed within 10 min, and the color variation produced by 150 nM of Hep can be distinguished by the naked eye. In addition, this strategy also shows good selectivity and sensitivity, and the linear range of Hep is from 10 to 400 nM with detection limit of 2.5 nM. Finally, this colorimetric assay has been applied to measure Hep in Hep sodium injection and human serum samples with satisfactory recoveries.
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c7nj02381b
WOS KeywordPEROXIDASE-LIKE ACTIVITY ; INDUCED THROMBOCYTOPENIA ; THROMBOPLASTIN TIME ; INDUCED EMISSION ; QUANTUM DOTS ; SULFATE ; ASSAY ; NANOCOMPOSITES ; NANOCLUSTERS ; SURFACTANT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (Youth Fund Project)(21405093) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000411768600011
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/9813
Collection中国科学院西北高原生物研究所
Corresponding AuthorQu, Fei; You, Jinmao
Affiliation1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Binzhou Cent Hosp, Binzhou Med Coll, Dept Clin Lab, Binzhou 256600, Shandong, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Qu, Fei,Liu, Yanqun,Lao, Haili,et al. Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles[J]. NEW JOURNAL OF CHEMISTRY,2017,41(19):10592-10597.
APA Qu, Fei,Liu, Yanqun,Lao, Haili,Wang, Yaping,&You, Jinmao.(2017).Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles.NEW JOURNAL OF CHEMISTRY,41(19),10592-10597.
MLA Qu, Fei,et al."Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles".NEW JOURNAL OF CHEMISTRY 41.19(2017):10592-10597.
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