Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways

doi:10.1016/j.jff.2017.07.042

NWIPB OpenIR

	Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways
	Jiang, Lei 1; Zhao, Xiaoying 2,3,4; Pei, Jinjin 1,5; Mei, Lijuan 1; Cui, Yulei 1,6; Wang, Shuo 1,6; Shao, Yun 1; Zhang, Xiaoling 2,3,4; Tao, Yanduo 1
	2017-10-01
发表期刊	JOURNAL OF FUNCTIONAL FOODS
ISSN	1756-4646
卷号	37 页码:594-602
文章类型	Article
摘要	Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases. (C) 2017 Elsevier Ltd. All rights reserved.
关键词	Evodiamine Zanthoxylum Bungeanum Rankl Osteoclast Differentiation Erk Nfatc1
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.jff.2017.07.042
关键词[WOS]	BONE LOSS ; CANCER ; PROLIFERATION ; APOPTOSIS ; OSTEOPOROSIS ; RESORPTION ; CALCIUM ; CELLS
收录类别	SCI
语种	英语
项目资助者	Natural Science Foundation of Qinghai(2016-ZJ-942Q) ; West Light Foundation of the Chinese Academy of Sciences(Y629071211) ; Important Qinghai Science & Technology Specific Projects(2014-GX-A3A-01) ; National Natural Science Foundation of China(81190133 ; Shanghai Municipal Natural Science Foundation(16ZR1441700 ; 81301548) ; 13ZR1424100)
WOS研究方向	Food Science & Technology
WOS类目	Food Science & Technology
WOS记录号	WOS:000412863400060
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/9828
专题	中国科学院西北高原生物研究所
通讯作者	Zhang, Xiaoling; Tao, Yanduo
作者单位	1.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med SJTUSM, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China 5.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources & Biol, Hanzhong 723001, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Lei,Zhao, Xiaoying,Pei, Jinjin,et al. Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways[J]. JOURNAL OF FUNCTIONAL FOODS,2017,37:594-602.
APA	Jiang, Lei.,Zhao, Xiaoying.,Pei, Jinjin.,Mei, Lijuan.,Cui, Yulei.,...&Tao, Yanduo.(2017).Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways.JOURNAL OF FUNCTIONAL FOODS,37,594-602.
MLA	Jiang, Lei,et al."Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways".JOURNAL OF FUNCTIONAL FOODS 37(2017):594-602.