NWIPB OpenIR
ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample
Huang, Lunjie1; Chen, Kai1; Zhang, Wentao1; Zhu, Wenxin1; Liu, Xinnan1; Wang, Jing1; Wang, Rong1; Hu, Na2; Suo, Yourui2; Wang, Jianlong1
2018-09-15
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume269Pages:87-95
SubtypeArticle
AbstractNanozyme technique with efficient modulating strategies is a promising tool for biocatalytic and biosensing applications, yet insights into target-responsive controllability of oxidase nanozymes remain largely unknown. In this contribution, we report a state-of-art oxidase-like and ssDNA-tunable nanozyme for biomolecular recognition. In detail, the spinel-type manganese cation substituted cobalt oxide (MnCo2O4) submicrospheres can imitate oxidase for efficiently catalytic oxidation of colorimetric substrate, superior to current metal oxide-based oxidase nanozymes. More importantly, the nanozyme activity of spinel MnCo2O4 can be reversibly inhibited by the attachment/detachment of aptamer strands on MnCo2O4 surface via the aptamer-target binding event, enabling a new colorimetric access for detecting biomolecules. Taking highly toxic ochratoxin A (OTA) as model molecule, we can selectively determine OTA in maize samples with a limit of detection (3 delta/S) of 0.08 ng/mL. The unique nanozyme property of spinel MnCo2O4, together with the principle of our approach, reveals the potential of ssDNA-tailorable oxidase nanozymes in biocatalytic and biosensing fields. (C) 2018 Elsevier B.V. All rights reserved.
KeywordActivity Modulation Aptamer Biosensor Food Analysis Nanozyme Oxidase
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1016/j.snb.2018.04.150
WOS KeywordPEROXIDASE-LIKE ACTIVITY ; COLORIMETRIC DETECTION ; NANOZYME ACTIVITY ; VISIBLE-LIGHT ; QUANTUM DOTS ; COCOA BEANS ; OCHRATOXIN ; NANOPARTICLES ; DNA ; APTASENSOR
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21675127) ; Fundamental Research Funds for the Central Universities(2014YB093 ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) ; 2452015257)
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000433211100012
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13793
Collection中国科学院西北高原生物研究所
Corresponding AuthorWang, Jianlong
Affiliation1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810008, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Huang, Lunjie,Chen, Kai,Zhang, Wentao,et al. ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,269:87-95.
APA Huang, Lunjie.,Chen, Kai.,Zhang, Wentao.,Zhu, Wenxin.,Liu, Xinnan.,...&Wang, Jianlong.(2018).ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample.SENSORS AND ACTUATORS B-CHEMICAL,269,87-95.
MLA Huang, Lunjie,et al."ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample".SENSORS AND ACTUATORS B-CHEMICAL 269(2018):87-95.
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