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Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography
Dang, Jun1,2; Cui, Yulei1,2; Pei, Jinjin1,3; Yue, Huilan1,2; Liu, Zenggen1,2; Wang, Weidong1,2; Jiao, Lijin1,2; Mei, Lijuan1,2; Wang, Qilan1,2; Tao, Yanduo1,2; Shao, Yun1,2
2018-03-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:3
文章类型Article
摘要An efficient preparative procedure for the separation of four antibacterial diterpenes from a Salvia prattii crude diterpenes-rich sample was developed. Firstly, the XION hydrophilic stationary phase was chosen to separate the antibacterial crude diterpenes-rich sample (18.0 g) into three fractions with a recovery of 46.1%. Then, the antibacterial fractions I (200 mg), II (200 mg), and III (150 g) were separated by the Megress C18 preparative column, and compounds tanshinone IIA (80.0 mg), salvinolone (62.0 mg), cryptotanshinone (70.0 mg), and ferruginol (68.0 mg) were produced with purities greater than 98%. The procedure achieved large-scale preparation of the four diterpenes with high purity, and it could act as a reference for the efficient preparation of active diterpenes from other plant extracts.
关键词Salvia Prattii Antibacterial Diterpenes Hydrophilic Solid-phase Extraction Preparative High-performance Liquid Chromatography
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.3390/molecules23030623
关键词[WOS]COUNTER-CURRENT CHROMATOGRAPHY ; MILTIORRHIZA-BUNGE ; TANSHINONES ; PURIFICATION ; CELLS
收录类别SCI
语种英语
项目资助者High and New Technology Research and Development Planning, Significant Science & Technological Project of Qinghai Province(2014-GX-A3A) ; Natural Science Funds of Qinghai Province(2016-ZJ-933Q) ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(ZSTH-027) ; West Light Foundation of the Chinese Academy of Sciences for Doctors ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2017471)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000428514100114
出版者MDPI
引用统计
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13839
专题中国科学院西北高原生物研究所
通讯作者Tao, Yanduo; Shao, Yun
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
2.Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
3.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources, Hanzhong 723000, Peoples R China
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GB/T 7714
Dang, Jun,Cui, Yulei,Pei, Jinjin,et al. Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography[J]. MOLECULES,2018,23(3).
APA Dang, Jun.,Cui, Yulei.,Pei, Jinjin.,Yue, Huilan.,Liu, Zenggen.,...&Shao, Yun.(2018).Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography.MOLECULES,23(3).
MLA Dang, Jun,et al."Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography".MOLECULES 23.3(2018).
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