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Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography
Dang, Jun1,2; Cui, Yulei1,2; Pei, Jinjin1,3; Yue, Huilan1,2; Liu, Zenggen1,2; Wang, Weidong1,2; Jiao, Lijin1,2; Mei, Lijuan1,2; Wang, Qilan1,2; Tao, Yanduo1,2; Shao, Yun1,2
2018-03-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:3
SubtypeArticle
AbstractAn efficient preparative procedure for the separation of four antibacterial diterpenes from a Salvia prattii crude diterpenes-rich sample was developed. Firstly, the XION hydrophilic stationary phase was chosen to separate the antibacterial crude diterpenes-rich sample (18.0 g) into three fractions with a recovery of 46.1%. Then, the antibacterial fractions I (200 mg), II (200 mg), and III (150 g) were separated by the Megress C18 preparative column, and compounds tanshinone IIA (80.0 mg), salvinolone (62.0 mg), cryptotanshinone (70.0 mg), and ferruginol (68.0 mg) were produced with purities greater than 98%. The procedure achieved large-scale preparation of the four diterpenes with high purity, and it could act as a reference for the efficient preparation of active diterpenes from other plant extracts.
KeywordSalvia Prattii Antibacterial Diterpenes Hydrophilic Solid-phase Extraction Preparative High-performance Liquid Chromatography
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.3390/molecules23030623
WOS KeywordCOUNTER-CURRENT CHROMATOGRAPHY ; MILTIORRHIZA-BUNGE ; TANSHINONES ; PURIFICATION ; CELLS
Indexed BySCI
Language英语
Funding OrganizationHigh and New Technology Research and Development Planning, Significant Science & Technological Project of Qinghai Province(2014-GX-A3A) ; Natural Science Funds of Qinghai Province(2016-ZJ-933Q) ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(ZSTH-027) ; West Light Foundation of the Chinese Academy of Sciences for Doctors ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2017471)
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000428514100114
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13839
Collection中国科学院西北高原生物研究所
Corresponding AuthorTao, Yanduo; Shao, Yun
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
2.Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
3.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources, Hanzhong 723000, Peoples R China
Recommended Citation
GB/T 7714
Dang, Jun,Cui, Yulei,Pei, Jinjin,et al. Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography[J]. MOLECULES,2018,23(3).
APA Dang, Jun.,Cui, Yulei.,Pei, Jinjin.,Yue, Huilan.,Liu, Zenggen.,...&Shao, Yun.(2018).Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography.MOLECULES,23(3).
MLA Dang, Jun,et al."Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography".MOLECULES 23.3(2018).
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